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Table 4 LOAEL symptoms of the DBPCFC-positive children

From: Double-blind placebo-controlled food challenges in children with alleged cow’s milk allergy: prevention of unnecessary elimination diets and determination of eliciting doses

Patient

Age (months)

Sex

Amount of CMP (mg)

Symptoms

Acute reactions

 

29

7,5

F

?

ery

30

134

M

?

os, nau

35

115

M

18

sw

63

4

M

18

ery

108

42,5

F

18

os, vom, sw

34

10

M

180

ery

90

26

F

360

ery, ur

42

14,5

M

540

ur

93

3

M

540

col

6

3,5

M

720

ery

107

7

M

720

cry, vom

14

5,5

M

1080

ery, ur

85

5

M

1080

dia

104

119

M

1080

ap, nau

47

11

M

1620

ery, vom, dysp, whe

54

8,5

F

1620

vom

59

7,5

M

1620

ery

66

24

F

1620

ery

87

7

F

1620

ec

95

6

M

1620

cry, dia

114

11

F

1620

dia, ery, cry, agi

121

17

M

1620

ery, ur

123

4

F

1620

agi, fp

Late reactions

 

9

7,5

F

1620

dia, cry

19

12,5

M

1620

sp, ery

21

6

M

1620

ec, con

27

5,5

M

1620

dysp

32

5,5

M

1620

ec, cry

37

2,5

F

1620

agi

39

5

F

1620

cry

62

13

F

1620

col, cry, con

65

7

F

1620

con

73

7

M

1620

agi, cry, dia

76

15,5

F

1620

cry, sp

79

7,5

F

1620

vom, cry

86

5

F

1620

dia

103

4

M

1620

agi

111

4,5

F

1620

con

  1. DBPCFC, double-blinded placebo-controlled food challenge; LOAEL, lowest observed adverse effect level; agi, agitation; ap, abdominal pain; col, colic; con, constipation; cry, crying; dia, diarrhea; dysp, dyspnea; ec, worsening eczema; ery, erythema; fp, feeding problems; itch, itching; nau, nausea; os, oropharyngeal symptoms; sw, swelling; ur, urticaria; vom, vomiting; whe, wheezing; sp, sleeping problems. Amounts of 18, 180, 360, 540, 720, 1080 and 1620 mg CMP correspond with 1, 10, 20, 30, 40, 60 and 90 ml test feeding respectively.