Skip to main content

Table 4 LOAEL symptoms of the DBPCFC-positive children

From: Double-blind placebo-controlled food challenges in children with alleged cow’s milk allergy: prevention of unnecessary elimination diets and determination of eliciting doses

Patient Age (months) Sex Amount of CMP (mg) Symptoms
Acute reactions  
29 7,5 F ? ery
30 134 M ? os, nau
35 115 M 18 sw
63 4 M 18 ery
108 42,5 F 18 os, vom, sw
34 10 M 180 ery
90 26 F 360 ery, ur
42 14,5 M 540 ur
93 3 M 540 col
6 3,5 M 720 ery
107 7 M 720 cry, vom
14 5,5 M 1080 ery, ur
85 5 M 1080 dia
104 119 M 1080 ap, nau
47 11 M 1620 ery, vom, dysp, whe
54 8,5 F 1620 vom
59 7,5 M 1620 ery
66 24 F 1620 ery
87 7 F 1620 ec
95 6 M 1620 cry, dia
114 11 F 1620 dia, ery, cry, agi
121 17 M 1620 ery, ur
123 4 F 1620 agi, fp
Late reactions  
9 7,5 F 1620 dia, cry
19 12,5 M 1620 sp, ery
21 6 M 1620 ec, con
27 5,5 M 1620 dysp
32 5,5 M 1620 ec, cry
37 2,5 F 1620 agi
39 5 F 1620 cry
62 13 F 1620 col, cry, con
65 7 F 1620 con
73 7 M 1620 agi, cry, dia
76 15,5 F 1620 cry, sp
79 7,5 F 1620 vom, cry
86 5 F 1620 dia
103 4 M 1620 agi
111 4,5 F 1620 con
  1. DBPCFC, double-blinded placebo-controlled food challenge; LOAEL, lowest observed adverse effect level; agi, agitation; ap, abdominal pain; col, colic; con, constipation; cry, crying; dia, diarrhea; dysp, dyspnea; ec, worsening eczema; ery, erythema; fp, feeding problems; itch, itching; nau, nausea; os, oropharyngeal symptoms; sw, swelling; ur, urticaria; vom, vomiting; whe, wheezing; sp, sleeping problems. Amounts of 18, 180, 360, 540, 720, 1080 and 1620 mg CMP correspond with 1, 10, 20, 30, 40, 60 and 90 ml test feeding respectively.