Consumption of cranberry polyphenols enhances human γδ-T cell proliferation and reduces the number of symptoms associated with colds and influenza: a randomized, placebo-controlled intervention study

Table 3 Immune cell proliferation ^a fold change ^b after cranberry beverage consumption

Cell type	Placebo beverage	Cranberry beverage	P
γδ-T cell^c	1.20 ± 0.26^f	3.86 ± 0.50	<0.001
NK^d cell^e	0.15 ± 0.12	0.33 ± 0.19	0.068
αβ-T cell^c	-0.16 ± 0.09	-0.16 ± 0.08	0.602
Monocyte^e	-0.11 ± 0.29	-0.30 ± 0.45	0.883
B cells^e	0.81 ± 0.16	1.32 ± 0.40	0.235

^aAfter isolation (Day 0), cells were placed into culture in RPMI-1640 with autologous serum and PHA-L, IL-2 and IL-15 for 6 days ^bA ratio of cultured cell numbers (Day 6/Day 0) was used to calculate proliferation fold changes. Baseline fold change values were subtracted from values obtained at 10 wk ^cPercentage of the CD3⁺ population determined by 2-color staining ^dNK, natural killer ^ePercentage of total cells ^fWilcoxon/Kruskal-Wallis rank sums test was used to determine significant differences. Values were calculated for each subject and the mean ± SEM determined.

ISSN: 1475-2891