Effects of lifestyle changes including specific dietary intervention and physical activity in the management of patients with chronic hepatitis C - a randomized trial

Table 7 Groups of weight loss and liver function parameters in patients with LFD

		Weight gain		1-5% weight loss		5-10% weight loss		Weight loss >10%		p
		Mean	SD	Mean	SD	Mean	SD	Mean	SD
PA (min/week)	Baseline	19.5	7.1	30.5	19.0	31.2	22.2	15.0	.	0.620
	12-months	33.8	11.1	71.5	36.6	70.6	34.5	85.0	.	0.229
Weight (kg)	Baseline	88.9	15.4	82.8	11.0	81.2	10.5	96.0	.	0.412
	12-months	90.3	15.2	80.8	11.1	75.2	10.3	84.0	.	0.090
BMI (kg/m²)	Baseline	30.4	4.1	29.2	3.2	29.5	3.9	32.4	.	0.774
	12-months	30.9	4.1	28.5	3.2	27.4	3.8	28.4	.	0.334
AST (IU/l)	Baseline	61.5	56.2	60.0	35.3	65.1	33.0	48.0	.	0.950
	12-months	63.7	57.8	50.3	31.5	55.7	31.0	36.0	.	0.811
ALT (IU/l)	Baseline	63.3	43.4	74.0	44.6	73.2	39.5	69.0	.	0.972
	12-months	77.1	72.9	56.0	40.3	67.8	41.0	42.0	.	0.671
Albumin (g/dl)	Baseline	4.3	0.5	4.2	0.5	4.3	0.4	3.8	.	0.692
	12-months	4.4	0.3	4.3	0.3	4.4	0.3	3.7	.	0.186
Bi (g/dl)	Baseline	0.7	0.2	0.7	0.3	0.6	0.2	0.8	.	0.579
	12-months	0.7	0.1	0.7	0.2	0.6	0.2	0.6	.	0.514
GGT (IU/l)	Baseline	71.3	55.5	59.9	28.0	73.1	36.3	55.0	.	0.592
	12-months	67.5	67.5	48.5	26.6	57.3	34.5	46.0	.	0.654
AST/ALT	Baseline	0.9	0.2	0.9	0.3	1.0	0.4	0.7	.	0.763
	12-months	0.9	0.2	1.0	0.2	0.9	0.2	0.9	.	0.424
FI	Baseline	5.4	1.7	5.6	1.4	5.7	1.3	4.6	.	0.863
	12-months	5.2	1.8	5.3	1.4	5.5	1.3	4.6	.	0.904
APRI	Baseline	0.7	0.6	0.8	0.6	0.8	0.5	0.3	.	0.866
	12-months	0.7	0.6	0.6	0.6	0.7	0.4	0.3	.	0.887

LFD low fat diet, PA physical activity, BMI body mass index, AST aspartate aminotransferase, ALT alanine aminotransferase, Bi bilirubin, GGT gamma-glutamyl transpeptidase, AST/ALT aspartate aminotransferase/alanine aminotransferase ratio, FI Forns fibrosis index, APRI AST to platelet ratio index.

ISSN: 1475-2891