Table 5 Summary of 3 on-going studies

Cabana 2010⁵⁷

USA

>37 weeks gestation, birth weight >2500 g and < 4500 g, 14±3 days of age on enrollment, singleton birth, non- breastfed, not received solid foods.

1) Study group 1: Test starter infant formula

Primary: Weight gain (g/day) at 14 to 112 days of life (4 months)

2) Study group 2: Test starter infant formula with synbiotics

3) Control /placebo group: Standard formula

Secondary: Tolerance, morbidity, protein status, metabolic markers December 2011

Zegerman 2009⁵⁸

Israel

37th and 42 week gestation, birth weight > 2500 g, recruitment age: 0–28 days, non-breastfed

1) Study group 1: Dietary Supplement: probiotic microorganism and/or prebiotic

Primary: weight, length, head circumference

2) Dietary Supplement: probiotic microorganism and/or prebiotic

Secondary: Microbiology August 2012

3) Dietary Supplement: probiotic microorganism and /or prebiotic

Ye 2010⁵⁹

Singapore

> 37 weeks to < 42 weeks gestation, singleton birth. Age at enrolment < 14 days old

1) Study group 1: Standard infant formula with prebiotics

Primary: Mean Weight gain

2) Study group: Infant formula with synbiotics

Secondary: Digestive tolerance December 2011