Table 1 Basic characteristics of included studies
Study | Participant characteristics | Short description of intervention | Total folate intake*(μg/day) | Mean duration of intervention** | Health outcomes | ||
|---|---|---|---|---|---|---|---|
Country | Age | No. in intervention and control groups | |||||
Baumslag 1970 [25] | South Africa | N/A | 65; 63a and 62; 52b | 200 mg iron + 5 mg FA/day | 8620a; 8747b | 16 wka and 12 wkb | birth weight |
200 mg iron/day | 120a; 247b | ||||||
Iyengar 1971 [26] | India | N/A | 23; 26 | 60 mg iron + 300 μg FA/day | 757 | 18 wk | birth weight |
60 mg iron/day | 247 | ||||||
Iyengar 1975 [27] | India | N/A | 98; 91 | 60 mg iron + 500 μg FA/day | 1097 | 16 wk | birth weight; placental weight |
60 mg iron/day | 247 | ||||||
Klingler 2006 [24] | Spain | 18-40 y | 16; 12 | 400 μg 5-MTHF/day | 647 | 20 wk | birth weight; placental weight; length of gestation |
11; 16 | placebo/day | 247 | |||||
fish oil + 400 μg 5- MTHF/day | 647 | ||||||
fish oil/day | 247 | ||||||
Lira 1989 [19] | Chile | 26.8±4.3 y 26.6±5.3 y | 75; 78 | 105 mg iron + 350 μg FA/day | 842 | 24 wk | length of gestation |
105 mg iron/day | 247 | ||||||
Nogueira 2002 [23] | Brasil | 13-18 y | 15; 13 | 120 mg iron sulphate + 250 μg FA/day | 545 | 22 wk | birth weight; length of gestation |
120 mg iron sulphate/day | 120 | ||||||
Rolschau 1979 [33] | Denmark | N/A | 20; 16 | 250 mg ferrofumarate + 5 mg FA/day | 8747 | 17 wk | birth weight; placental weight; length of gestation |
250 mg ferrofumarate/day | 247 | ||||||
Tchernia 1982 [28] | France | N/A | 54; 54 | iron + μg FA/day | 842 | 12 wk | birth weight; placental weight; length of gestation |
iron/day | 247 | ||||||