Table 2 Association between one-carbon metabolism related nutrients intake and disease progression in breast cancer patients
|  | All (N = 980) | Events (N = 141) | Model 1a | Model 2b |
|---|---|---|---|---|
Vitamin B2 intake, mg | Â | Â | Â | Â |
 Continuous (mean(SD)) | 1.0 (0.4) | 1.0 (0.4) | 1.21 (0.67-2.18) | 1.29 (0.71-2.33) |
 1st quartile (0.1-0.6) | 192 (19.6) | 29 (20.6) | 1.00 | 1.00 |
 2nd quartile (0.7-0.8) | 226 (23.1) | 26 (18.4) | 0.94 (0.54-1.61) | 0.99 (0.58-1.73) |
 3rd quartile (0.9-1.1) | 295 (30.1) | 44 (31.2) | 1.20 (0.71-2.02) | 1.28 (0.75-2.18) |
 4th quartile (1.2-3.4) | 267 (27.2) | 42 (29.8) | 1.40 (0.76-2.61) | 1.58 (0.84-2.98) |
 P trend |  |  | 0.21 | 0.12 |
Vitamin B6 intake, mg | Â | Â | Â | Â |
 Continuous (mean(SD)) | 1.5 (0.5) | 1.5 (0.6) | 1.41 (0.90-2.20) | 1.38 (0.88-2.17) |
 1st quartile (0.1-1.0) | 174 (17.8) | 26 (18.4) | 1.00 | 1.00 |
 2nd quartile (1.1-1.3) | 262 (26.7) | 39 (27.7) | 1.27 (0.75-2.16) | 1.28 (0.75-2.18) |
 3rd quartile (1.4-1.7) | 238 (24.3) | 27 (19.2) | 0.97 (0.72-1.80) | 0.98 (0.53-1.83) |
 4th quartile (1.8-4.8) | 306 (31.2) | 49 (34.8) | 1.61 (0.82-3.16) | 1.65 (0.84-3.24) |
 P trend |  |  | 0.29 | 0.27 |
Folate intake, mg | Â | Â | Â | Â |
 Continuous (mean(SD)) | 213.8 (99.3) | 212.9 (98.3) | 1.00 (0.99-1.00) | 1.00 (0.99-1.00) |
 1st quartile (9–147) | 240 (24.5) | 37 (26.2) | 1.00 | 1.00 |
 2nd quartile (148–199) | 248 (25.3) | 32 (22.7) | 0.82 (0.51-1.33) | 0.82 (0.51-1.34) |
 3rd quartile (200–256) | 247 (25.2) | 33 (23.4) | 0.96 (0.58-1.60) | 0.97 (0.58-1.63) |
 4th quartile (257–970) | 245 (25.0) | 39 (27.7) | 1.18 (0.68-2.03) | 1.20 (0.69-2.07) |
 P trend |  |  | 0.50 | 0.46 |
Combined score | Â | Â | Â | Â |
 Low (0) | 302 (30.8) | 44 (31.2) | 1.00 | 1.00 |
 Medium (1–2) | 289 (29.5) | 35 (24.8) | 0.92 (0.58-1.47) | 0.93 (0.58-1.50) |
 High (3) | 389 (39.7) | 62 (44.0) | 1.40 (0.84-2.33) | 1.46 (0.87-2.43) |
 P trend |  |  | 0.20 | 0.15 |