Pharmacokinetics of a single oral dose of vitamin D3 (70,000 IU) in pregnant and non-pregnant women

Nutrition Journal

Table 1 Changes in [25(OH)D] following a single dose of 70,000 IU vitamin D3 in non-pregnant and pregnant women in Dhaka, Bangladesh ^a

	All participants	Non-pregnant	Pregnant	P ^b
N (all participants)	61	34	27
Baseline [25(OH)D] (N=61)
Mean [95% CI]	47 [42, 52]	54 [47, 62]	39 [34, 45]	0.010
Range	21, 96	27, 96	21, 95
Δ[25(OH)D], Mean [95% CI], nmol/L
Day 2 (N=27)	20 [15,25]	24 [17, 33]	15 [11,22]	0.037
Day 4 (N=27)	23 [18, 30]	24 [17, 34]	23 [16, 32]	0.800
Day 7 (N=29)	26 [21, 33]	25 [18, 34]	28 [20, 40]	0.134
Day 21 (N=14)	25 [18, 35]	21 [14, 33]	32 [20, 51]	0.003
Day 56 (N=12)	16 [11,23]	14 [9,21]	20 [12, 33]	0.101
Participants in single-dose only groups
N (% followed more than 7 days)	31 (51%)	18 (53%)	13 (48%)
# Specimens per participant
Median	6	6	6
Range	3, 6	3, 6	3, 6
Baseline [25(OH)D] (N=31)
Mean [95% CI]	48 [41, 56]	52 [42, 64]	43 [34, 55]	0.224
Range	21, 96	27, 96	21, 95
Tmax, days (N=31)
Mean [95% CI]	11 [7,18]	9 [4,17]	17 [10,29]	0.134
Range	2, 70	2, 70	2, 70
Cmax, nmol/L (N=31)
Mean [95% CI]	85 [77, 93]	87 [75, 101]	82 [72, 92]	0.500
Range	51, 164	51, 164	52, 116
ΔCmax, nmol/L (N=31)
Mean [95% CI]	30 [23, 39]	28 [18, 42]	33 [24, 46]	0.486
Range	2, 87	2, 87	9, 52
Area under the curve, nmol·d/L ^c
AUC_56/70, Mean (N=30)	935	910	969	0.863
[95% CI]	[651, 1343]	[531, 1559]	[563, 1668]	0.863
AUC_28/35, Mean (N=31)	591	562	632	0.672
[95% CI]	[448, 780]	[383, 823]	[398, 1003]	0.672
ΔCavg _28/35 per mg dose ^d (nmol/L/mg)
[95% CI]	12 [10,15]	12 [8,15]	14 [10,18]	0.370

^a. [25(OH)D] summary measures are geometric means with exponentiated 95% confidence intervals, unless otherwise indicated.
^b. One-way analysis of variance (ANOVA) test for difference between non-pregnant and pregnant groups.
^c. AUC was only estimated using data from participants with follow-up to the end of the interval of interest (i.e., 28/35 days or 56/70 days).
^d. Average [25(OH)D] over the first 28 or 35 days, per mg of the single vitamin D3 dose. Arithmetic means and 95% confidence intervals reported because these estimates had an approximately normal distribution.

ISSN: 1475-2891