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Table 8 Multi regression analysis in which MTHFR polymorphism, Homocysteine level, HCV genotype and lipid profile as a independent variables for fibrosis1+2

From: Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and high plasma homocysteine in chronic hepatitis C (CHC) infected patients from the Northeast of Brazil

Variables OR (CI 95%) p* OR adjusted p OR adjusted p
Gender: F/M 0.9 (0.5-1.7) 0.87 1.1 (0.5-2.4) 0.85 1.1 (0.5-2.4) 0.82
HOM- ≥ 2.5 0.8 (0.4-1.8) 0.55 0.8 (0.4-1.8) 0.63 0.8 (0.4-1.8) 0.57
LDL cholesterol ≥ 130 2.1 (0.4-10) 0.51 2.2 (0.4-11.1) 0.34 -(**) -
HDL cholesterol ≤ 40 1.0 (0.4-2.3) 1.00 1.3 (0.6-3.2) 0.51 1.3 (0.5-3.2) 0.53
Tot-l Cholesterol ≥ 200 1.7 (0.3-8.3) 0.73 -(**) - 1.8 (0.3-9.2) 0.49
Triglyceride ≥ 150 1.4 (0.4-5.3) 0.76 1.3 (0.3-5.0) 0.70 1.3 (0.3-5.1) 0.72
TT+CT (MTHFR) 0.9 (0.5-1.7) 0.75 1.4 (0.7-3.1) 0.39 1.4 (0.6-3.1) 0.39
Homocysteine ≥ 9 0.6 (0.3-1.3) 0.17 0.7(0.3-1.5) 0.34 0.7 (0.3-1.5) 0.35
  1. *Fisher Test ** Collinearity
  2. References values:
  3. Triglyceride < 150 mg/dL, Total Cholesterol < 200 mg/dL, LDL-c < 130 mg/dL, HDL-c > 40 mg/dL, HOMA: < 2.5, Homocysteine < 9.0 μmol/L.
  4. CI: confidence interval
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