Placebo (n = 19) | Q10-300 (n = 20) | |||||
---|---|---|---|---|---|---|
Week 0 | Week 12 | Week 12-0b | Week 0 | Week 12 | Week 12-0 | |
coenzyme Q10 (μM) | 0.32 ± 0.14 (0.33)a | 0.38 ± 0.09 (0.37) | 0.11 ± 0.15 (0.09) | 0.27 ± 0.08 (0.27) | 1.47 ± 0.82 (1.58)e,d | 1.19 ± 0.84 (1.35)d |
vitamin E (μM) | 11.84 ± 2.98 (11.66) | 12.04 ± 4.13 (11.47) | 0.20 ± 2.79 (0.51) | 11.16 ± 2.20 (12.10) | 11.52 ± 3.28 (10.54) | 0.43 ± 2.29 (0.54) |
Oxidative stress | ||||||
MDA (μM) | 1.37 ± 0.34 (1.42) | 1.41 ± 0.30 (1.37) | 0.08 ± 0.35 (0.11) | 1.48 ± 0.58 (1.33) | 1.22 ± 0.31 (1.10)e,d | −0.27 ± 0.68 (−0.33)d |
Antioxidant enzymes activity | ||||||
SOD (U/mg protein) | 16.94 ± 8.78 (13.10) | 17.12 ± 5.79 (16.90) | 0.73 ± 11.37 (3.00) | 13.93 ± 4.35 (13.16) | 21.26 ± 7.86 (22.02)e,d | 7.96 ± 7.15 (7.50)d |
CAT (U/mg protein) | 16.36 ± 7.97 (12.00) | 15.24 ± 6.62 (12.80) | −1.71 ± 6.25 (0.29) | 14.74 ± 7.63 (11.75) | 18.00 ± 6.82 (16.76)e,d | 3.28 ± 7.76 (4.80)d |
GPx (U/mg protein) | 15.22 ± 5.76 (14.66) | 12.73 ± 5.46 (12.20) | −1.10 ± 7.26 (−0.60) | 15.94 ± 4.77 (17.46) | 19.40 ± 8.34 (22.08)e,d | 4.08 ± 7.67 (4.70)d |
Inflammatory markers | ||||||
hs-CRP (mg/L) | 3.5 ± 3.6 (1.6) | 2.1 ± 3.9 (0.8) | −1.5 ± 4.2 (−0.8) | 4.2 ± 4.2 (2.8) | 2.6 ± 4.2 (1.0)e | −1.7 ± 4.8 (−1.3) |
TNF-α (pg/mL) | 0.89 ± 0.71 (1.16) | 1.77 ± 4.38 (0.73) | 0.88 ± 4.59 (−0.10) | 0.84 ± 0.78 (0.73) | 1.06 ± 1.02 (0.86) | 0.30 ± 1.19 (0.02) |
IL-6 (pg/mL) | 3.76 ± 2.30 (3.44) | 2.83 ± 3.64 (1.34) | −1.05 ± 3.72 (−1.65) | 3.07 ± 2.03 (1.98) | 1.62 ± 0.75 (1.70)e | −0.49 ± 2.96 (−0.70) |