Parameter reduction | Day | Placebo (n = 53) | GC (n = 57) | UC-II (n = 54) | p value | |||
---|---|---|---|---|---|---|---|---|
Overalla | GC vs PBO | UC-II vs PBOb | UC-II vs GCc | |||||
WOMAC pain | 7 | 3.21 ± 0.58 | 4.57 ± 0.54 | 3.88 ± 0.55 | - | - | - | - |
30 | 6.61 ± 1.04 | 7.89 ± 1.00 | 9.18 ± 1.01 | - | - | - | - | |
60 | 8.17 ± 1.10 | 10.1 ± 1.07 | 12.7 ± 1.09 | 0.0149 | - | 0.011 | - | |
90 | 11.2 ± 1.17 | 12.7 ± 1.14 | 16.4 ± 1.16 | 0.0063 | - | 0.0059 | - | |
120 | 12.9 ± 1.28 | 15.6 ± 1.22 | 19.9 ± 1.26 | 0.0005 | - | 0.0004 | 0.040 | |
150 | 15.0 ± 1.21 | 17.5 ± 1.16 | 21.5 ± 1.20 | 0.0007 | - | 0.0006 | 0.047 | |
180 | 17.0 ± 1.25 | 19.2 ± 1.20 | 24.0 ± 1.23 | 0.0003 | - | 0.0003 | 0.016 | |
WOMAC stiffness | 7 | 3.47 ± 0.64 | 4.22 ± 0.61 | 4.24 ± 0.62 | - | - | - | - |
30 | 6.81 ± 1.10 | 8.76 ± 1.05 | 9.28 ± 1.07 | - | - | - | - | |
60 | 9.36 ± 1.28 | 11.5 ± 1.25 | 13.1 ± 1.27 | - | - | - | - | |
90 | 11.3 ± 1.36 | 13.8 ± 1.32 | 17.0 ± 1.35 | 0.0158 | - | 0.010 | - | |
120 | 13.6 ± 1.40 | 15.0 ± 1.34 | 20.0 ± 1.39 | 0.0035 | - | 0.0039 | 0.029 | |
150 | 15.5 ± 1.32 | 17.7 ± 1.26 | 21.3 ± 1.31 | 0.0079 | - | 0.0058 | - | |
180 | 17.8 ± 1.31 | 19.4 ± 1.27 | 23.8 ± 1.30 | 0.0043 | - | 0.004 | 0.044 | |
WOMAC physical function | 7 | 3.17 ± 0.56 | 4.14 ± 0.53 | 3.91 ± 0.53 | - | - | - | - |
30 | 6.30 ± 1.00 | 7.80 ± 0.96 | 9.26 ± 0.98 | - | - | - | - | |
60 | 7.75 ± 1.08 | 9.50 ± 1.05 | 11.9 ± 1.07 | 0.0278 | - | 0.020 | - | |
90 | 10.4 ± 1.17 | 12.1 ± 1.14 | 15.1 ± 1.16 | 0.0182 | - | 0.0136 | - | |
120 | 12.7 ± 1.20 | 14.5 ± 1.15 | 17.9 ± 1.19 | 0.0083 | - | 0.0064 | - | |
150 | 14.8 ± 1.19 | 16.9 ± 1.14 | 20.0 ± 1.18 | 0.0078 | - | 0.006 | - | |
180 | 17.3 ± 1.21 | 18.8 ± 1.16 | 22.5 ± 1.20 | 0.0068 | - | 0.007 | - |