From: Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review
Reference | Study Design | Sample Population | Intervention | Control | Length of Treatment | Outcomes | Direction of Evidence | Reported Adverse Events |
---|---|---|---|---|---|---|---|---|
Carroll (2000) [75] | Randomized; Double-blind; Parallel Group | 80 healthy males | Berocca: oral multivitamin1 | Placebo | 28 days | Multivitamin treatment significantly reduced anxiety as measured by GHQ-28, HADS and PSS. | + | Not reported |
De Souza (2000) [76] | Randomized; Double-blind; Crossover (4) | 44 women with adverse premenstrual symptoms but otherwise in good health | (1) 200 mg Mg, (2) 50 mg vitamin B6, (3) 200 mg Mg + 50 mg vitamin B6 per day | Placebo | One menstrual cycle | 200 mg/day Mg + 50 mg/day vitamin B6 significantly reduced anxiety-related premenstrual symptoms | + | Participants were not specifically asked, but none were reported spontaneously |
Hanus (2004) [77] | Randomized; Double-blind; Parallel Group | 264 patients with generalized anxiety (DSM-III-R) of mild-to-moderate intensity2 | Sympathyl: extracts of crataegus oxyacantha and eschscholtzia californica plus magnesium | Placebo | 3 months | Significant clinical improvement in anxiety3 in favour of the combination treatment | + | No serious AEs related to treatment4 |