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Table 3 Treatment effect in hemoglobin, ferritin and total iron concentrations of children

From: Efficacy of different strategies to treat anemia in children: a randomized clinical trial

Evaluation

IS

IFS

MMS

FW

FCF

p

Hemoglobin

(g/dL)

     

N

40

42

36

48

51

 

Baseline

10.45 (10.18, 10.72)

10.72 (10.49, 10.95)

10.73 (10.52, 10.94)

10.55 (10.32, 10.78)

10.51 (10.22, 10.80)

0.487

Final

11.94 (11.60, 12.27)1

12.24 (11.90, 12.58)1

12.14 (11.80, 12.48)1

11.62 (11.28, 11.96)

11.38 (11.07, 11.68)2

0.001

Change

1.49 (1.13, 1.84)†1

1.52 (1.13, 1.91)†1

1.41 (1.05, 1.76)†1

1.07 (0.77, 1.36)†

0.86 (0.60, 1.13)†2

0.012

Adjusted change *

1.43 (1.05, 1.80)

1.58 (1.26, 1.89)1

1.46 (1.08, 1.83)1

1.25 (0.89, 1.62)

0.94 (0.65, 1.22)2

0.034

Ferritin

(μg/dL)

     

N‡

29

32

23

38

46

 

Baseline

30.04 (9.90, 50.18)

72.18 (41.64, 102.71)

22.83 (2.97, 42.69)

60.93 (36.55, 85.31)

57.95 (31.18, 84.72)

0.073

Final

55.50 (26.79, 84.22)

51.24 (26.83, 75.64)

20.53 (4.12, 36.94)

48.16 (21.33, 74.98)

60.45 (32.26, 88.63)

0.366

Change

25.47 (3.97, 46.96)†1

-20.94 (-44.78, 2.89)2

-2.30 (-10.61, 6.01)

-12.77 (-35.49, 9.95)2

2.49 (-17.90, 22.89)

0.042

Adjusted change *

21.43 (-4.05, 46.91)

0.94 (-19.50, 21.38)

0.67 (-24.96, 26.30)

-4.06 (-26.80, 18.69)

20.29 (2.97, 37.62)

0.200

Total Iron

(μg/dL)

     

N‡

26

30

21

33

46

 

Baseline

1.05 (0.90, 1.20)

1.01 (0.86, 1.16)

1.04 (0.88, 1.19)

1.17 (0.99, 1.34)

1.04 (0.90, 1.17)

0.822

Final

1.26 (1.08, 1.45)

1.16 (1.03, 1.29)

1.26 (1.02, 1.50)

1.35 (1.17, 1.53)

1.23 (1.09, 1.38)

0.604

Change

0.21 (0.08, 0.35)†

0.15 (0.04, 0.26)†

0.23 (0.04, 0.42)†

0.19 (0.06, 0.31)†

0.20 (0.10, 0.29)†

0.932

Adjusted change *

0.16 (0.00, 0.31)

0.13 (0.01, 0.25)

0.16 (0.00, 0.32)

0.25 (0.11, 0.39)

0.16 (0.05, 0.26)

0.771

  1. Treatment abbreviations: Iron supplement (IS), iron plus folic acid supplement (IFS), multiple micronutrients supplement (MMS), micronutrient fortified complementary food as porridge powder (FCF), or zinc, iron and ascorbic acid fortified water (FW).
  2. Values are means (95% CI).
  3. * Estimated changes adjusted for initial value, consumed iron in the treatment (according to formula and adherence to the treatment) and community.
  4. † Change is significant within treatment at p < 0.05 in paired T-Test
  5. ‡ Excludes children with positive C-Reactive Protein from qualitative analysis
  6. 1,2 Different numbers indicate significant difference in the Least Significant Test at p < 0.05.