scFOS dose (g/d) | Excess flatus | Bloating | Borborygmi | Abdominal pain |
---|
| d1-d8* | d8-d15* | P** | d1-d8* | d8-d15* | P** | d1-d8* | d8-d15* | P** | d1-d8* | d8-d15* | P** |
---|
0 (placebo) | 4.12 ± 1.35 | 4.12 ± 1.45 | *** | 3.87 ± 1.80 | 2.62 ± 0.92 | *** | 3.25 ± 1.80 | 2.75 ± 1.47 | *** | 1.50 ± 1.00 | 0.50 ± 0.26 | *** |
2.5 | 1.75 ± 0.45 | 3.62 ± 1.28 | NS | 1.50 ± 0.42 | 3.12 ± 1.28 | 0.03 | 1.37 ± 0.49 | 300 ± 1.36 | NS | 1.12 ± 0.61 | 1.12 ± 0.61 | NS |
5.0 | 3.00 ± 1.08 | 5.25 ± 1.71 | NS | 1.75 ± 0.97 | 3.37 ± 1.76 | 0.03 | 1.75 ± 0.92 | 2.87 ± 1.42 | NS | 0.87 ± 0.51 | 0.87 ± 0.51 | NS |
7.5 | 3.50 ± 0.86 | 3.50 ± 0.68 | NS | 1.75 ± 1.03 | 1.50 ± 0.62 | NS | 1.75 ± 0.64 | 0.62 ± 0.32 | NS | 2.12 ± 0.87 | 2.12 ± 0.87 | NS |
10 | 3.37 ± 1.16 | 4.75 ± 1.03 | NS | 2.25 ± 1.06 | 2.62 ± 1.16 | NS | 1.50 ± 0.75 | 1.62 ± 0.86 | NS | 2.12 ± 0.81 | 2.12 ± 0.81 | NS |
- *days 1–8 was a run-in period during which no treatment occurred, but subjects excluded from their diet fermented dairy products containing viable bifidobacteria and limited consumption of food products containing high level of non-digestible oligosaccharides.
- ** Statistical analyses were performed versus placebo, on the difference d15-d8, using Fisher's Test
- *** As the difference days 15-8 with placebo was the reference, p-values are not reported. Symptom intensity was noted every day using a 4-grade scale 0: no symptom; 1: mild symptoms; 2: moderate symptoms; 3: severe symptoms. Cumulative daily scores were calculated for each period [d1, d8 a.m.], [d8 p.m., d15] and are reported in the present table as m ± sem. Severity of symptoms and cumulative daily scores can be related via the following scale: 0: no symptom; 1–7: mild symptoms; 8–14: moderate symptoms; 15–21: severe symptoms.