Variable | Changed apo A-V levels | |||||
---|---|---|---|---|---|---|
Total subjects | TT allele | C allele (TC and CC) | ||||
Regression coefficients | P-value | Regression coefficients | P-value | Regression coefficients | P-value | |
[95% CI†] | [95% CI†] | [95% CI†] | ||||
APOA5 -1131 T > C genotype | −24.532 [−47.596, −1.469] | 0.037 | - | - | - | - |
Age | 0.427 [−0.839, 1.693] | 0.507 | 0.477 [−1.512, 2.465] | 0.634 | −0.204 [−1.880, 1.471] | 0.809 |
Baseline levels | ||||||
Body mass index | 1.078 [−3.811, 5.966] | 0.664 | 0.812 [−6.501, 8.124] | 0.826 | 2.696 [−4.004, 9.396] | 0.426 |
Apo A-V∮ | −107.870 [−132.432, −83.308] | <0.001 | −112.767 [−151.730, −73.804] | <0.001 | −101.958 [−133.939, −69.976] | <0.001 |
Triglycerides∮ | −17.959 [−43.321, 7.402] | 0.164 | −19.362 [−61.602, 22.877] | 0.364 | −14.284 [−48.109, 19.542] | 0.404 |
HDL cholesterol∮ | 24.125 [−31.326, 79.576] | 0.392 | −2.779 [−88.093, 82.536] | 0.948 | 49.796 [−27.506, 127.097] | 0.204 |
Glucose∮ | −33.234 [−182.983, 116.516] | 0.662 | −210.610 [−463.912, 42.691] | 0.102 | 129.957 [−64.812, 324.727] | 0.188 |
HOMA-IR∮ | 22.975 [−12.858, 58.809] | 0.207 | 12.221 [−49.304, 73.746] | 0.693 | 14.817 [−30.146, 59.781] | 0.514 |
Free fatty acids∮ | 26.503 [−4.251, 57.257] | 0.551 | 42.963 [−5.154, 91.081] | 0.079 | 9.158 [−32.164, 50.480] | 0.661 |
Changed levels | ||||||
Triglycerides∮ | 0.066 [−0.152, 0.284] | 0.551 | −0.404 [−0.784, −0.024] | 0.038 | 0.349 [0.085, 0.612] | 0.010 |
HDL cholesterol∮ | 2.550 [1.455, 3.645] | <0.001 | 3.280 [1.274, 5.287] | 0.002 | 2.239 [0.915, 3.563] | 0.001 |
Glucose∮ | −0.121 [−1.018, 0.775] | 0.790 | −0.631 [−2.905, 1.643] | 0.582 | −0.363 [−1.397, 0.671] | 0.487 |
HOMA-IR∮ | −4.036 [−17.793, 9.721] | 0.563 | 0.119 [−22.914, 23.152] | 0.992 | −8.468 [−25.418, 8.481] | 0.324 |
Free fatty acids∮ | 0.085 [0.034, 0.135] | 0.001 | 0.079 [−0.005, 0.164] | 0.065 | 0.071 [0.006, 0.137] | 0.034 |
R 2 = 0.459, adjusted R 2 = 0.416 | R 2 = 0.524, adjusted R 2 = 0.440 | R 2 = 0.525, adjusted R 2 = 0.455 | ||||
P < 0.001 | P < 0.001 | P < 0.001 |