|  | Pvalue | ||||
---|---|---|---|---|---|---|
Variables | Baseline | 2Â months | 6Â months | Time | Diet | TimexDiet |
 Weight, kg | 102.8 ± 2.2a | 95.4 ± 2.1b | 94.4 ± 2.2b | < 0.001 | 0.834 | 0.666 |
 BMI, kg/m 2 | 36.1 ± 0.6a | 33.5 ± 0.5b | 33.2 ± 0.6b | < 0.001 | 0.997 | 0.474 |
 WC, cm | 114.2 ± 1.6a | 106.8 ± 1.5b | 105.7 ± 1.6b | < 0.001 | 0.999 | 0.102 |
DXA measurements | Â | Â | Â | Â | Â | Â |
 Fat mass, kg | 42.9 ± 1.2a | 37.5 ± 1.2b | 36.3 ± 1.2c | < 0.0011 | 0.469 | 0.432 |
 Muscle mass, kg | 56.6 ± 1.5a | 54.5 ± 1.4b | 54.8 ± 1.5b | < 0.001 | 0.694 | 0.239 |
Biochemical variables | Â | Â | Â | Â | Â | Â |
 Cholesterol, mg/dL | 219 ± 5a | 197 ± 5b | 219 ± 5a | < 0.001 | 0.568 | 0.751 |
 Glucose, mg/dL | 128 ± 5a | 111 ± 3b | 116 ± 4b | 0.0011 | 0.786 | 0.377 |
 TG, mg/dL | 195 ± 13a | 146 ± 10b | 154 ± 12b | < 0.0011 | 0.730 | 0.955 |
 FFA, mmol/L | 0.56 ± 0.21a | 0.52 ± 0.24a,b | 0.47 ± 0.20b | 0.016 | 0.122 | 0.461 |
 CRP, mg/L | 4.3 ± 0.7 a | 3.1 ± 0.4a,b | 2.5 ± 0.4b | 0.0051 | 0.597 | 0.183 |
 HOMA index, mM/L | 4.9 ± 0.4a | 2.8 ± 0.3b | 3.0 ± 0.4b | < 0.001 | 0.956 | 0.288 |
 Leptin, ng/mL | 21.5 ± 2.1a | 14.5 ± 1.5c | 17.2 ± 1.9b | < 0.001 | 0.816 | 0.837 |
 Insulin, μU/mL | 15.4 ± 1.1a | 9.7 ± 0.9b | 9.6 ± 1.0b | < 0.0011 | 0.964 | 0.634 |
BDI questionnaire | 7.6 ± 0.8a | 4.4 ± 0.6b | 3.8 ± 0.7c | < 0.001 | 0.777 | 0.798 |
Activity level2 | 1.6 ± 0.1 | 1.6 ± 0.1 | 1.6 ± 0.1 | 0.154 | 0.697 | 0.184 |