Eicosapentaenoic and docosahexaenoic acid supplementation and inflammatory gene expression in the duodenum of obese patients with type 2 diabetes

Table 3 Inflammatory gene expression in duodenal tissue after EPA + DHA and placebo supplementation in 12 men with type 2 diabetes

	Placebo	EPA + DHA	Difference	P
	mRNA copies/10⁵copies ATP5o		Difference	P
IL-6	8 (9)	10 (3)	2	0.77
TNF-α	109 (51)	93 (50)	−16	0.75
IL-18	5226 (3552)	5398 (1486)	172	0.73
STAT3	4637 (1723)	4646 (1437)	9	0.91

Data are expressed as median and interquartile range in parentheses. P values were calculated using Wilcoxon matched-pairs signed-rank tests. Abbreviations: ATP5o, ATP synthase O subunit; DHA, docosahexaenoic acid; EPA, eicosapentaenoic acid; IL, interleukin; mRNA, messenger ribonucleic acid; STAT3, signal transducer and activator of transcription 3; TNF-α, tumor necrosis factor α.

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