Nutrition Journal

Table 3 Association between median of one-carbon metabolism related nutrients and disease progression in breast cancer patients stratified by clinicopathological characteristics

From: Prognosis of breast cancer is associated with one-carbon metabolism related nutrients among Korean women

		Below median		Above median
		No. of total	No. of events	No. of total	No. of events	HR (95%CI)^a
	TNM stage
Vitamin B₂, mg	I-II	350	39	466	58	1.40 (0.85-2.30)
	III	68	16	96	28	1.13 (0.52-2.43)
Vitamin B₆, mg	I-II	362	46	454	51	1.02 (0.61-1.73)
	III	74	19	90	25	1.05 (0.49-2.27)
Folate, mg	I-II	397	48	419	49	1.10 (0.69-1.75)
	III	91	21	73	23	1.52 (0.77-3.01)
	Lymph-node status
Vitamin B₂, mg	Negative	242	25	335	35	1.28 (0.67-2.42)
	Positive	172	29	218	49	1.40 (0.81-2.44)
Vitamin B₆, mg	Negative	251	28	326	32	1.22 (0.63-2.34)
	Positive	181	36	209	42	0.88 (0.49-1.56)
Folate, mg	Negative	284	30	293	30	1.23 (0.68-2.24)
	Positive	199	38	191	40	1.12 (0.67-1.87)
	Hormone status
Vitamin B₂, mg	ER + and/or PR+	300	34	398	40	0.91 (0.52-1.59)
	ER–/PR–	111	21	153	43	2.28 (1.20-4.35)
Vitamin B₆, mg	ER + and/or PR+	305	39	393	35	0.57 (0.32-1.03)
	ER–/PR–	125	26	139	38	1.86 (0.97-3.56)
Folate, mg	ER + and/or PR+	333	39	365	35	0.82 (0.49-1.40)
	ER–/PR–	148	30	116	34	1.84 (1.02-3.32)
	Nuclear grade
Vitamin B₂, mg	I-II	223	23	302	34	1.22 (0.64-2.34)
	III	185	32	241	50	1.43 (0.82-2.49)
Vitamin B₆, mg	I-II	226	29	299	28	0.56 (0.28-1.11)
	III	200	36	226	46	1.28 (0.73-2.24)
Folate, mg	I-II	250	31	275	26	0.69 (0.38-1.27)
	III	224	38	202	44	1.59 (0.95-2.66)

Abbreviation: ER, estrogen receptor; PR, progesterone receptor.
^a Adjusted for age, education, recruited site, TNM stage, hormone status, nuclear grade and total calorie.

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ISSN: 1475-2891

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