Influence of the relative composition of trace elements and vitamins in physicochemical stability of total parenteral nutrition formulations for neonatal use

Table 3 Lipid particles diameter sizes calculated OM, DLS and LO (PFAT ₅ ), in NP1, NP2 and NP3

Time	T (°C)	OM^a (nm)	DLS		PFAT₅(%)
Time	T (°C)	OM^a (nm)	z-average (nm)	PDI	PFAT₅(%)
NP1
0 h	25	810 ± 270	275 ± 24	0.091	0.05 ± 2 · 10^-3
48 h	5	870 ± 111	269 ± 16	0.085	0.05 ± 1 · 10^-3
	25	400 ± 250	275 ± 10	0.105	0.03 ± 1 · 10^-3
	40	800 ± 360	270 ± 01	0.065	0.02 ± 2 · 10^-3
7 days	5	750 ± 250	271 ± 09	0.065	0.04 ± 1 · 10^-3
	25	560 ± 170	274 ± 08	0.045	0.03 ± 1 · 10^-3
	40	480 ± 370	272 ± 11	0.055	0.04 ± 1 · 10^-3
NP2
0 h	25	760 ± 320	280 ± 12	0.035	0.02 ± 1 · 10^-3
48 h	5	950 ± 450	268 ± 30	0.050	0.02 ± 4 · 10^-4
	25	810 ± 320	267 ± 27	0.065	0.02 ± 6 · 10^-4
	40	630 ± 240	262 ± 21	0.055	0.01 ± 5 · 10^-4
7 days	5	620 ± 180	257 ± 14	0.045	0.02 ± 8 · 10^-4
	25	650 ± 240	274 ± 02	0.035	0.01 ± 4 · 10^-4
	40	540 ± 190	264 ± 14	0.105	0.01 ± 3 · 10^-4
NP3
0 h	25	580 ± 190	272 ± 06	0.053	0.05 ± 1 · 10^-3
48 h	5	600 ± 180	279 ± 14	0.065	0.05 ± 8 · 10^-4
	25	650 ± 240	272 ± 05	0.075	0.05 ± 6 · 10^-4
	40	880 ± 450	274 ± 04	0.065	0.05 ± 5 · 10^-4
7 days	5	520 ± 170	272 ± 06	0.065	0.04 ± 9 · 10^-4
	25	610 ± 190	268 ± 13	0.060	0.05 ± 1 · 10^-3
	40	640 ± 210	270 ± 07	0.065	0.05 ± 1 · 10^-3

number of determinations = 3; results are presented as average ± SD. ^amedium droplet size.

ISSN: 1475-2891