| Pain | Stiffness | Function | ||||||
---|---|---|---|---|---|---|---|---|---|
 | 30 days | 60 days | 90 days | 30 days | 60 days | 90 days | 30 days | 60 days | 90 days |
UP446 500 mgs vs. UP446 250 mgs | NS* | NS | 0.038 | NS | NS | NS | NS | NS | NS |
UP446 250 mgs vs. CELECOXIB 200 mgs | NS | NS | NS | NS | NS | NS | 0.010 | NS | NS |
UP446 500 mgs vs. CELECOXIB 200 mgs | 0.020 | NS | NS | NS | NS | NS | 0.015 | 0.043 | 0.039 |
UP446 250 mgs vs. PLACEBO | NS | NS | NS | 0.000 | 0.027 | 0.015 | 0.010 | 0.043 | 0.039 |
UP446 500 mgs vs. PLACEBO | 0.044 | 0.032 | 0.001 | 0.001 | NS | 0.005 | 0.015 | 0.016 | 0.003 |
CELECOXIB 200 mgs vs. PLACEBO | NS | 0.009 | NS | 0.023 | NS | NS | 0.015 | 0.016 | 0.003 |