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Table 2 Relationship between energy-adjusted macronutrient intakes and risk of esophageal squamous cell carcinoma in a case-control study in Iran

From: Macronutrients, vitamins and minerals intake and risk of esophageal squamous cell carcinoma: a case-control study in Iran

Macronutrients

Tertiles of Intake1OR (95%CI)

 

Model 12

Model 23

 

Tertile1 5

Tertile2

Tertile3

P-trend 6

Tertile 1 4

Tertile 2

Tertile 3

P-trend 5

Total energy, Kcal Number

1.00 (46)

0.80 (0.24-2.13) (48)

1.11 (0.25-1.98) (49)

0.52

1.00

0.62 (0.03-2.65)

1.23 (0.86-2.14)

0.29

Total fat, g Number

1.00 (46)

1.23 (1.04-2.95) (46)

1.94(1.05-3.28) (51)

0.02

1.00

1.11 (0.80-2.67)

1.48 (1.09-3.04)

0.005

SFA, g Number

1.00 (48)

1.70 (1.21-4.93) (47)

3.52 (1.10-3.89) (48)

0.01

1.00

1.32 (1.20-2.93)

2.88 (1.15-3.08)

0.01

PUFA, g Number

1.00 (47)

2.83 (0.34-3.60) (48)

0.71 (0.13-1.62) (48)

0.98

1.00

1.19 (0.42-2.57)

0.98 (0.31-2.64)

0.14

MUFA, g Number

1.00 (48)

1.39 (0.95 -2.79) (47)

1.39 (0.29-2.16) (48)

0.23

1.00

0.97 (0.15-1.74)

1.19 (0.42-2.75)

0.81

(n-3)fatty acids, g Number

1.00 (48)

0.42 (0.21-0.75) (47)

0.51 (0.08-0.90) (48)

0.01

1.00

0.86 (0.16-0.97)

0.32 (0.07-0.84)

<0.001

Dietary fiber, g Number

1.00 (48)

0.72 (0.31-2.18) (47)

0.46 (0.01-0.88) (48)

<0.001

1.00

0.71 (0.02-2.03)

0.29 (0.13-0.76)

0.02

Carbohydrate, g Number

1.00 (46)

0.70 (0.31-2.93) (46)

0.17 (0.06-0.92) (51)

0.04

1.00

0.79 (0.32-1.56)

0.22 (0.05-0.84)

<0.001

Protein, g Number

1.00 (48)

1.25 (0.59-2.74) (48)

1.61 (1.49-4.13) (47)

<0.02

1.00

1.13 (0.54-1.64)

1.93 (0.60-3.18)

0.52

Cholesterol, mg Number

1.00 (47)

0.92 (0.09-1.39) (49)

3.71(1.49-2.60) (47)

<0.001

1.00

0.68 (0.22-1.73)

1.53 (1.41-4.13)

<0.001

Vegetable Oil, g 6 Number

1.00 (47)

0.59 (0.21-3.58) (47)

0.95 (0.16-2.24) (49)

0.87

1.00

1.25 (0.35-1.93)

1.44 (0.08-2.23)

0.61

Discretionary calorie, % total energy intake 7 Number

1.00 (48)

1.68 (1.07-3.95) (48)

2.33(1.58-2.90) (47)

<0.001

1.00

1.17 (1.02-2.65)

1.51 (1.06-3.84)

0.002

  1. OR: Odds ratio; CI: Confidence interval; SFA: Saturated fatty acid; PUFA: Poly unsaturated fatty acid; MUFA: Mono unsaturated fatty acid
  2. 1Nutrient intakes are adjusted for energy intake using the residual method [56]
  3. 2Base model; adjusted for age (years) and sex (male/female)
  4. 3Fully-adjusted model; adjusted for age (years), sex (male/female), gastroesophageal reflux disease symptoms (yes/no), body mass index (≤24.9, >24.9 kg/m2), smoking status (never/former/current), smoking intensity and duration (<20, ≥20 pack-years), physical activity (MET) (light/heavy), and education level (illiterate, literate)
  5. 4Reference category
  6. 5The P-value for trend was calculated using the linear regression coefficient for the tertiles of macronutrient intake
  7. 6Described as fat from vegetable oil, fish, nuts and seeds sources
  8. 7Described as the energy derived from solid fat and added sugar