The effects of folic acid supplementation on endothelial function in adults: a systematic review and dose-response meta-analysis of randomized controlled trials

Table 4 GRADE profile of folic acid for endothelial function parameters

Outcomes	Risk of bias	Inconsistency	Indirectness	Imprecision	Publication Bias	Quality of evidence
EDD	No serious limitation	Very serious limitation^a	No serious limitation	Serious limitation^b	No serious limitation	⊕◯◯◯ Very low
FMD%	No serious limitation	Very serious limitation^a	No serious limitation	No serious limitation	No serious limitation	⊕⊕◯◯ Low
FMD	No serious limitation	Very serious limitation^a	No serious limitation	No serious limitation	No serious limitation	⊕⊕◯◯ Low
ICAM	No serious limitation	Very serious limitation^a	No serious limitation	Serious limitation^b	No serious limitation	⊕◯◯◯ Very low

^aThere is high heterogeneity (I² > 75%) for EDD, FMD%, FMD and ICAM
^bThere is no evidence of significant effects of folic acid supplementation on EDD, and ICAM

ISSN: 1475-2891