Table 3 Subgroup analyses of acid folic supplementation on endothelial function in adults

 Overall effect

9

0.21 (−0.09, 0.52)

0.176

< 0.001

88.8%

   < 8

6

−0.01 (−0.11, 0.08)

0.766

0.998

0.0%

0.351

   ≥ 8

3

0.79 (−0.90, 2.48)

0.359

< 0.001

96.7%

   < 5

1

−0.01 (−0.19, 0.17)

0.914

–

–

0.211

   ≥ 5

8

0.26 (−0.12, 0.65)

0.184

< 0.001

90.1%

  CVD

6

0.04 (−0.10, 0.19)

0.558

0.072

50.6%

0.654

  No-CVD

3

0.48 (−1.44, 2.42)

0.621

< 0.001

96.6%

 Overall effect

7

2.59 (1.51, 3.67)

< 0.001

< 0.001

90.0%

   < 8

3

4.90 (2.09, 7.71)

0.001

< 0.001

90.2%

0.010

   ≥ 8

4

1.17 (0.86, 1.48)

< 0.001

0.675

0.0%

   < 5

1

6.14 (4.17, 8.10)

< 0.001

–

–

< 0.001

   ≥ 5

6

2.08 (1.11, 3.05)

< 0.001

< 0.001

87.3%

  CVD

3

4.67 (1.44, 7.89)

0.004

< 0.001

90.3%

0.063

  No-CVD

4

1.51 (0.68, 2.34)

< 0.001

0.001

82.2%

 Overall effect

10

24.38 (3.08, 45.68)

0.025

< 0.001

98.6%

   < 8

7

26.72 (−8.07, 61.53)

0.132

< 0.001

98.6%

0.745

   ≥ 8

3

18.72 (−14.53, 51.99)

0.270

< 0.001

98.4%

   < 5

2

−2.95 (−11.62, 5.71)

0.504

0.760

0.0%

0.014

   ≥ 5

8

31.05 (5.30, 56.80)

0.018

< 0.001

98.9%

  CVD

7

36.16 (3.35, 68.98)

0.031

< 0.001

98.6%

0.035

  No-CVD

3

0.02 (−6.88, 6.93)

0.994

0.168

43.9%

 Overall effect

3

0.18 (−10.02, 13.81)

0.755

0.004

82.1%