Skip to main content

Table 3 Blood-based biological outcomes measured in the trial

From: Cognitive and biological effects of citrus phytochemicals in subjective cognitive decline: a 36-week, randomized, placebo-controlled trial

Biological marker

Method of measurement

Neuronal damage

BDNF, IGF-1

ELISA

NF-light

Simoa SR-X, quanterix

Oxidative stress

Nitric oxide, thiobarbituric acid reactive substances, superoxide dismutase

ELISA

Inflammation

Pro-inflammatory cytokines

*CXCL8/IL-8, IL-1beta, IL-6, IL-17, TNF-alpha, IP10, MIP-1alfa, CCL2/MCP-1, CCL5/RANTES, IL-18

Bio-plex 200, Bio-Rad

Anti-inflammatory molecules

IL-10, IL1-Ra, soluble TNF receptor I, soluble TNF receptor II

Bio-plex 200, Bio-Rad

  1. BDNF Brain-Derived Neurotrophic Factor, IGF Insulin-like Growth Factor, NF NeuroFilament, CXCL8 C-X-C motif Chemokine Ligand 8, IL InterLeukin, TNF Tumour Necrosis Factor, IP Interferon γ-induced Protein, MIP Macrophage Inflammatory Protein, CCL2/MCP-1 C–C motif Chemokine Ligand 2/Monocyte Chemoattractant Protein-1, CCL5/RANTES C–C motif Chemokine Ligand 5/ Regulated on Activation Normal T cell Expressed and Secreted, Ra Receptor antagonist
  2. *Secondary endpoint