Skip to main content

Table 3 The effects of 8 weeks’ soy isoflavones supplementation on migraine characteristics and clinical indices of migraine

From: Effect of soy isoflavones supplementation on migraine characteristics, mental status and calcitonin gene-related peptide (CGRP) levels in women with migraine: results of randomised controlled trial

Soy isoflavones group (n = 44)

Placebo group (n = 44)

P b

P c

 

Baseline

End of trial

Change

P a

Baseline

End of trial

Change

P a

Characteristics of migraine attack

  Attacks frequency

( per month)

7.65 ± 2.44

5.29 ± 1.95

-2.36 ± 1.20

 < 0.001

7.06 ± 1.43

6.63 ± 1.90

-0.43 ± 1.35

0.040

0.002

 < 0.001

  Severity

7.06 ± 1.63

6.13 ± 1.78

-0.93 ± 1.95

0.003

6.65 ± 1.62

6.34 ± 1.66

-0.31 ± 1.61

0.197

0.580

0.189

  Attacks duration (hr) 1

10.38. ± 4.35

7.88 ± 3.50

-2.50 ± 1.74

 < 0.001

10.61 ± 2.08

10.63 ± 2.80

-0.02 ± 2.15

0.944

 < 0.001

 < 0.001

Clinical indices of migraine

  MI

(frequency * severity)

55.77 ± 26.10

32.02 ± 14.65

-23.75 ± 18.19

 < 0.001

47.29 ± 15.94

42.75 ± 17.87

-4.54 ± 12.89

0.024

0.003

 < 0.001

  HDR

(frequency * duration)

80.04 ± 41.23

42.84 ± 26.29

-37.20 ± 22.38

 < 0.001

74.79 ± 24.23

70.13 ± 24.11

-4.65 ± 20.22

0.134

 < 0.001

 < 0.001

  MHIS

(frequency * duration * severity)

19.18 ± 11.24

8.72 ± 5.91

-10.46 ± 7.43

 < 0.001

16.59 ± 6.99

15.12 ± 6.90

-1.47 ± 5.25

0.069

 < 0.001

 < 0.001

  1. Variables expressed as mean ± SD
  2. a Paired t-test was used to compare pre-post tests
  3. b Independent sample t-test was used to compare groups two by two
  4. c Obtained from analysis of covariance in the adjusted models (adjusted for baseline value and certain dietary factors such as vitamin D, thiamin, riboflavin, niacin, cobalamin and magnesium)
  5. 1 Average duration of migraine attacks
  6. Abbreviations: MI Migraine index, HDR Headache diary result, MHIS Migraine headache index score