Skip to main content

Table 3 Interaction effect between serum 5-MeTHF (≤ 10 ng/mL) concentration and MTHFR C677T on Hcy concentration

From: Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study

Subgroups (5-MeTHF ng/mL) N Crude Model Adjusted Model
β (95% CI) P Value β (95% CI) P Value
Genotype CC
 Q1 (< 2.7) 115 Ref   Ref  
 Q2 (2.7 - < 4.4) 127 −0.74 (−3.10, 1.61) 0.536 0.35 (−1.79, 2.51) 0.745
 Q3 (4.4 - < 6.4) 119 −1.1 7 (−3.57, 1.22) 0.337 −0.04 (−2.25, 2.17) 0.973
 Q4 (≥ 6.4) 124 −1.12 (−3.49, 1.25) 0.355 −0.01 (−2.23, 2.22) 0.996
Genotype CT
 Q1 (< 2.7) 213 1.53 (−0.59, 3.65) 0.157 1.21 (−0.72, 3.15) 0.217
 Q2 (2.7 - < 4.4) 204 0.55 (−1.59, 2.68) 0.615 0.54 (−1.41, 2.51) 0.583
 Q3 (4.4 - < 6.4) 226 −0.37 (−2.47, 1.73) 0.729 0.52 (−1.44, 2.49) 0.602
 Q4 (≥ 6.4) 226 −1.39 (−3.49, 0.71) 0.195 0.11 (−1.88, 2.11) 0.910
Genotype TT
 Q1 (< 2.7) 132 15.80 (13.67, 18.14) <  0.001 14.77 (12.63, 16.92) <  0.001
 Q2 (2.7 - < 4.4) 129 8.16 (5.81, 10.51) <  0.001 8.00 (5.83, 10.17) <  0.001
Q3 (4.4 - < 6.4) 114 7.07 (4.65, 9.49) <  0.001 7.22 (4.94, 9.50) <  0.001
 Q4 (≥ 6.4) 111 2.60 (0.16, 5.03) 0.037 3.46 (1.17, 5.75) 0.003
P for trend    <  0.001   <  0.001
P for interaction    <  0.001   <  0.001
  1. Adjusted for sex, age, study site, BMI, systolic blood pressure, diastolic blood pressure, estimated glomerular filtration rate, total cholesterol, triglycerides, high-density lipoprotein cholesterol, vitamin B12, vitamin D3, fasting glucose, folate, smoking and drinking at baseline