|
Subgroups (5-MeTHF ng/mL)
|
N
|
Crude Model
|
Adjusted Model
|
|---|
|
β (95% CI)
|
P Value
|
β (95% CI)
|
P Value
|
|---|
|
Genotype CC
|
|
Q1 (< 2.7)
|
115
|
Ref
| |
Ref
| |
|
Q2 (2.7 - < 4.4)
|
127
|
−0.74 (−3.10, 1.61)
|
0.536
|
0.35 (−1.79, 2.51)
|
0.745
|
|
Q3 (4.4 - < 6.4)
|
119
|
−1.1 7 (−3.57, 1.22)
|
0.337
|
−0.04 (−2.25, 2.17)
|
0.973
|
|
Q4 (≥ 6.4)
|
124
|
−1.12 (−3.49, 1.25)
|
0.355
|
−0.01 (−2.23, 2.22)
|
0.996
|
|
Genotype CT
|
|
Q1 (< 2.7)
|
213
|
1.53 (−0.59, 3.65)
|
0.157
|
1.21 (−0.72, 3.15)
|
0.217
|
|
Q2 (2.7 - < 4.4)
|
204
|
0.55 (−1.59, 2.68)
|
0.615
|
0.54 (−1.41, 2.51)
|
0.583
|
|
Q3 (4.4 - < 6.4)
|
226
|
−0.37 (−2.47, 1.73)
|
0.729
|
0.52 (−1.44, 2.49)
|
0.602
|
|
Q4 (≥ 6.4)
|
226
|
−1.39 (−3.49, 0.71)
|
0.195
|
0.11 (−1.88, 2.11)
|
0.910
|
|
Genotype TT
|
|
Q1 (< 2.7)
|
132
|
15.80 (13.67, 18.14)
|
< 0.001
|
14.77 (12.63, 16.92)
|
< 0.001
|
|
Q2 (2.7 - < 4.4)
|
129
|
8.16 (5.81, 10.51)
|
< 0.001
|
8.00 (5.83, 10.17)
|
< 0.001
|
|
Q3 (4.4 - < 6.4)
|
114
|
7.07 (4.65, 9.49)
|
< 0.001
|
7.22 (4.94, 9.50)
|
< 0.001
|
|
Q4 (≥ 6.4)
|
111
|
2.60 (0.16, 5.03)
|
0.037
|
3.46 (1.17, 5.75)
|
0.003
|
|
P for trend
| | |
< 0.001
| |
< 0.001
|
|
P for interaction
| | |
< 0.001
| |
< 0.001
|
- Adjusted for sex, age, study site, BMI, systolic blood pressure, diastolic blood pressure, estimated glomerular filtration rate, total cholesterol, triglycerides, high-density lipoprotein cholesterol, vitamin B12, vitamin D3, fasting glucose, folate, smoking and drinking at baseline
