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Table 2 Multiple linear regression model of Hcy on level of 5-MeTHF in all participants and stratified by MTHFR C677T genotype (5-MeTHF ≤ 10 ng/mL only)

From: Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study

5-MeTHF (ng/mL) N Hcy Adjusted model
Median (IQR) β (95% CI) P Value
All Participants
 Continuous 1840 13.8 (11.4, 17.5) −0.50 (− 0.69, − 0.31) <  0.001
 Quartiles
  Q1 (< 2.7) 460 15.3 (12.7, 20.1) Ref  
  Q2 (2.7 - < 4.4) 460 14.6 (11.7, 18.1) −2.18 (−3.32, −1.03) <  0.001
  Q3 (4.4 - < 6.4) 459 13.3 (11.3, 16.7) −2.51 (− 3.71, − 1.31) <  0.001
  Q4 (≥ 6.4) 461 12.5 (10.5, 15.2) −3.62 (−4.87, − 2.38) <  0.001
P for trend     <  0.001
Genotype CC
 Continuous 485 12.9 (10.8, 15.4) −0.14 (−0.30, 0.02) 0.087
 Quartiles
  Q1 (<  2.8) 121 14.0 (11.4, 16.2) Ref  
  Q2 (2.8 - < 4.5) 121 12.9 (11.1, 15.5) −0.22 (− 1.20, 0.76) 0.662
  Q3 (4.5 - < 6.5) 121 12.3 (10.5, 14.7) −0.47 (− 1.48, 0.53) 0.353
  Q4 (≥ 6.5) 122 12.5 (10.3, 14.6) −0.98 (− 2.04, 0.08) 0.070
P for trend     0.061
Genotype CT
 Continuous 869 13.3 (11.2, 16.5) −0.20 (− 0.35, − 0.05) 0.011
 Quartiles
  Q1 (< 2.7) 217 14.7 (12.5, 18.1) Ref  
  Q2 (2.7 - < 4.5) 217 14.1 (11.5, 16.9) −0.64 (− 1.54, 0.27) 0.170
  Q3 (4.5 - < 6.5) 217 12.9 (11.2, 15.3) −0.79 (− 1.73, 0.16) 0.105
  Q4 (≥ 6.5) 218 12.0 (10.1, 14.5) −1.30 (−2.29, −0.30) 0.011
P for trend     0.013
Genotype TT
 Continuous 486 17.3 (13.3, 26.1) −1.19 (− 1.77, −0.62) <  0.001
 Quartiles
  Q1 (< 2.7) 122 21.0 (15.8, 35.7) Ref  
  Q2 (2.7 - < 4.1) 121 17.9 (14.3, 27.4) −5.92 (−9.46, −2.38) 0.001
  Q3 (4.1 - < 6.2) 121 17.1 (13.2, 24.5) −7.52 (−11.22, −3.81) <  0.001
  Q4 (≥ 6.2) 122 14.1 (11.7, 19.1) −9.02 (−12.84, −5.20) <  0.001
P for trend     <  0.001
  1. Adjusted for sex, age, study site, BMI, systolic blood pressure, diastolic blood pressure, estimated glomerular filtration rate, total cholesterol, triglycerides, high-density lipoprotein cholesterol, vitamin B12, vitamin D3, fasting glucose, folate, smoking and drinking at baseline