Table 1 Baseline characteristics of the study participants stratified by MTHFR C677T
Characteristics | Total (N = 2328) | MTHFR C677T | P Value | ||
|---|---|---|---|---|---|
CC (N = 691) | CT (N = 1129) | TT (N = 580) | |||
Age, years | 63.2 (57.5, 69.1) | 64.3 (57.5, 70.1) | 62.8 (57.5, 68.8) | 63.4 (57.6, 68.3) | 0.060 |
Male, n (%) | 1127 (48.3) | 290 (46.8) | 561 (49.7) | 275 (47.2) | 0.437 |
BMI, kg/m2 | 24.2 (21.8, 26.9) | 23.7 (21.2, 26.6) | 24.3 (22.0, 27.0) | 24.5 (21.9, 27.3) | 0.002 |
SBP, mmHg | 166.7 (156.0, 180.7) | 166.0 (156.7, 180.0) | 167.3 (155.3, 181.3) | 167.3 (156.0, 180.8) | 0.976 |
DBP, mmHg | 93.3 (86.0, 100.7) | 90.7 (83.3, 100.0) | 94.0 (86.0, 100.7) | 94.7 (87.3, 100.7) | <  0.001 |
eGFR, mL/min/1.73m2 | 92.2 (83.5, 99.1) | 91.7 (81.7, 99.0) | 92.7 (84.2, 99.0) | 92.0 (83.9, 99.5) | 0.286 |
TC, mmol/L | 5.4 (4.7, 6.2) | 5.3 (4.6, 6.1) | 5.4 (4.7, 6.2) | 5.5 (4.8, 6.3) | 0.011 |
TG, mmol/L | 1.4 (1.0, 1.9) | 1.3 (1.0, 1.9) | 1.4 (1.0, 1.9) | 1.3 (1.0, 1.9) | 0.754 |
HDL-C, mmol/L | 1.3 (1.1, 1.6) | 1.3 (1.1, 1.6) | 1.3 (1.1, 1.6) | 1.3 (1.1, 1.5) | 0.987 |
Vitamin B12, pg/mL | 382.9 (318.2, 478.5) | 391.2 (323.6, 485.2) | 388.0 (323.2, 485.2) | 367.6 (307.7, 453.3) | 0.001 |
Vitamin D3, ng/mL | 19.1 (13.7, 25.3) | 19.1 (14.3, 25.1) | 19.2 (13.6, 25.1) | 18.8 (13.5, 24.7) | 0.145 |
Glu, mmol/L | 5.4 (4.9, 6.1) | 5.3 (4.7, 6.0) | 5.4 (4.9, 6.2) | 5.4 (5.0, 6.2) | 0.001 |
Folate, ng/mL | 7.8 (5.3, 10.4) | 9.0 (6.2, 11.3) | 8.0 (5.5, 10.4) | 6.2 (4.6, 9.0) | <  0.001 |
5-MeTHF, ng/mL | 5.4 (3.1, 9.0) | 5.5 (3.1, 9.0) | 5.6 (3.2, 9.5) | 4.8 (2.8, 8.2) | 0.002 |
Hcy, μ mol/L | 13.4 (11.1, 16.8) | 12.6 (10.6, 15.2) | 13.0 (11.0, 15.5) | 16.4 (12.8, 24.9) | <  0.001 |