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Table 1 Baseline characteristics of the study participants stratified by MTHFR C677T

From: Association between serum 5-methyltetrahydrofolate and homocysteine in Chinese hypertensive participants with different MTHFR C677T polymorphisms: a cross-sectional study

Characteristics Total
(N = 2328)
MTHFR C677T P Value
CC
(N = 691)
CT
(N = 1129)
TT
(N = 580)
Age, years 63.2 (57.5, 69.1) 64.3 (57.5, 70.1) 62.8 (57.5, 68.8) 63.4 (57.6, 68.3) 0.060
Male, n (%) 1127 (48.3) 290 (46.8) 561 (49.7) 275 (47.2) 0.437
BMI, kg/m2 24.2 (21.8, 26.9) 23.7 (21.2, 26.6) 24.3 (22.0, 27.0) 24.5 (21.9, 27.3) 0.002
SBP, mmHg 166.7 (156.0, 180.7) 166.0 (156.7, 180.0) 167.3 (155.3, 181.3) 167.3 (156.0, 180.8) 0.976
DBP, mmHg 93.3 (86.0, 100.7) 90.7 (83.3, 100.0) 94.0 (86.0, 100.7) 94.7 (87.3, 100.7) <  0.001
eGFR, mL/min/1.73m2 92.2 (83.5, 99.1) 91.7 (81.7, 99.0) 92.7 (84.2, 99.0) 92.0 (83.9, 99.5) 0.286
TC, mmol/L 5.4 (4.7, 6.2) 5.3 (4.6, 6.1) 5.4 (4.7, 6.2) 5.5 (4.8, 6.3) 0.011
TG, mmol/L 1.4 (1.0, 1.9) 1.3 (1.0, 1.9) 1.4 (1.0, 1.9) 1.3 (1.0, 1.9) 0.754
HDL-C, mmol/L 1.3 (1.1, 1.6) 1.3 (1.1, 1.6) 1.3 (1.1, 1.6) 1.3 (1.1, 1.5) 0.987
Vitamin B12, pg/mL 382.9 (318.2, 478.5) 391.2 (323.6, 485.2) 388.0 (323.2, 485.2) 367.6 (307.7, 453.3) 0.001
Vitamin D3, ng/mL 19.1 (13.7, 25.3) 19.1 (14.3, 25.1) 19.2 (13.6, 25.1) 18.8 (13.5, 24.7) 0.145
Glu, mmol/L 5.4 (4.9, 6.1) 5.3 (4.7, 6.0) 5.4 (4.9, 6.2) 5.4 (5.0, 6.2) 0.001
Folate, ng/mL 7.8 (5.3, 10.4) 9.0 (6.2, 11.3) 8.0 (5.5, 10.4) 6.2 (4.6, 9.0) <  0.001
5-MeTHF, ng/mL 5.4 (3.1, 9.0) 5.5 (3.1, 9.0) 5.6 (3.2, 9.5) 4.8 (2.8, 8.2) 0.002
Hcy, μ mol/L 13.4 (11.1, 16.8) 12.6 (10.6, 15.2) 13.0 (11.0, 15.5) 16.4 (12.8, 24.9) <  0.001
  1. Values are median (interquartile range) or n (%). Differences in baseline characteristics were compared using chi-square test for categorical variables and Kruskal test for continuous variables. BMI body-mass index, SBP systolic blood pressure, DBP diastolic blood pressure, eGFR estimated glomerular filtration rate, TG triglycerides, TC total cholesterol, HDL-C high-density lipoprotein cholesterol, Glu glucose, 5-MeTHF 5-methyltetrahydrofolate, Hcy homocysteine