| |
Daily alcohol consumption categories (g of alcohol)
|
P- trend
|
|---|
|
No
|
< 23 g
|
23–46
|
≥ 46
|
|---|
|
Males
|
|
Incidence of CKD, n (%)
|
228 (3.1)
|
206 (3.3)
|
150 (3.5)
|
83 (4.7)
| |
|
IR per 1000PY
|
7.9
|
8.0
|
8.4
|
11.5
| |
|
Hazard ratio (95% CI)
|
|
Unadjusted model
|
1.0 (reference)
|
0.99 (0.83–1.21)
|
0.97 (0.79–1.20)
|
1.32 (1.03–1.70) *
|
.172
|
|
Adjusted model 1
|
1.0 (reference)
|
1.02 (0.84–1.23)
|
0.91 (0.73–1.12)
|
0.95 (0.73–1.24)
|
.432
|
|
Adjusted model 2
|
1.0 (reference)
|
1.03 (0.85–1.24)
|
0.91 (0.73–1.12)
|
0.96 (0.73–1.25)
|
.454
|
|
Adjusted model 3
|
1.0 (reference)
|
1.03 (0.85–1.24)
|
0.90 (0.73–1.11)
|
0.92 (0.71–1.20)
|
.342
|
|
Females
|
|
Incidence of CKD, n (%)
|
120 (3.0)
|
69 (3.5)
|
38 (5.0)
|
28 (7.7)
| |
|
IR per 1000PY
|
8.3
|
10.0
|
13.0
|
20.1
| |
|
Hazard ratio (95% CI)
|
|
Unadjusted model
|
1.0 (reference)
|
1.23 (0.91–1.65)
|
1.43 (0.99–2.06)
|
2.22 (1.47–3.36) *
|
< .001
|
|
Adjusted model 1
|
1.0 (reference)
|
1.23 (0.91–1.65)
|
1.21 (0.83–1.76) *
|
1.56 (1.01–2.39) *
|
.039
|
|
Adjusted model 2
|
1.0 (reference)
|
1.22 (0.91–1.65)
|
1.19 (0.81–1.76)
|
1.65 (1.06–2.56) *
|
.030
|
|
Adjusted model 3
|
1.0 (reference)
|
1.23 (0.91–1.65)
|
1.21 (0.83–1.79)
|
1.62 (1.04–2.53) *
|
.039
|
- PY person-years, CI confidence interval
- Multivariate model 1 adjusted for age (years) and eGFR (mL/min/1.73 m2) at baseline
- Model 2 adjusted for the covariates in model 1, body mass index (BMI) (kg/m2), and smoking status (never/former and current smokers)
- Model 3 adjusted for the covariates in model 2, and current treatment for comorbidities (hypertension, dyslipidemia, diabetes mellitus, and cardiovascular disease)
- *P < .05
- P-trend was derived from general linear models by treating alcohol consumption as a continuous linear term
