Skip to main content

Table 2 Alcohol consumption and the incidence of proteinuria in males and females

From: Association of alcohol consumption with the incidence of proteinuria and chronic kidney disease: a retrospective cohort study in Japan

 

Daily alcohol consumption categories (g of alcohol)

P-trend

No

 < 23 g

23–46

 ≥ 46

Males

 Incidence of proteinuria, n (%)

744 (10.1)

612 (9.7)

434 (10.2)

203 (11.5)

 

 IR per 1000PY

26.7

24.7

25.3

29.8

 

 Hazard ratio (95% CI)

  Unadjusted model

1.0 (reference)

0.92 (0.83–1.02)

0.93 (0.83–1.05)

1.10 (0.94–1.28)

.852

  Adjusted model 1

1.0 (reference)

0.94 (0.84–1.04)

0.99 (0.87–1.11)

1.14 (0.98–1.34)

.312

  Adjusted model 2

1.0 (reference)

0.97 (0.87–1.08)

1.00 (0.89–1.13)

1.17 (0.99–1.37)

.196

  Adjusted model 3

1.0 (reference)

0.97 (0.87–1.08)

0.99 (0.88–1.12)

1.14 (0.97–1.34)

.318

Females

 Incidence of proteinuria, n (%)

257 (6.4)

126 (6.5)

44 (5.8)

35 (9.7)

 

 IR per 1000PY

18.0

18.7

15.4

26.0

 

 Hazard ratio (95% CI)

  Unadjusted model

1.0 (reference)

1.03 (0.84–1.28)

0.86 (0.63–1.19)

1.44 (1.01–2.05) *

.369

  Adjusted model 1

1.0 (reference)

1.04 (0.84–1.29)

0.97 (0.71–1.34)

1.66 (1.16–2.37) *

.077

  Adjusted model 2

1.0 (reference)

1.04 (0.84–1.29)

0.93 (0.67–1.29)

1.59 (1.10–2.28) *

.140

  Adjusted model 3

1.0 (reference)

1.04 (0.84–1.29)

0.93 (0.67–1.30)

1.57 (1.10–2.26) *

.144

  1. PY person-years, CI confidence interval
  2. Multivariate model 1 adjusted for age (years) and eGFR (mL/min/1.73 m2) at baseline
  3. Model 2 adjusted for the covariates in model 1, body mass index (BMI) (kg/m2), and smoking status (never/former and current smokers)
  4. Model 3 adjusted for the covariates in model 2, and current treatment for comorbidities (hypertension, dyslipidemia, diabetes mellitus, and cardiovascular disease)
  5. *P < .05
  6. P-trend was derived from general linear models by treating alcohol consumption as a continuous linear term