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Table 1 Dosage information in FA supplementation and it’s relation with CHD or ASD

From: Evaluation of the association between maternal folic acid supplementation and the risk of congenital heart disease: a systematic review and meta-analysis

Authors (year) Intake of folic acid CHD OR (95% Cl) ASD OR (95% Cl)
Scanlon KS et al. (1998) [18] Low-dose group < 245 μg 1.11 (0.63, 2.00)  
Middle-dose group 245–355 μg 1  
High-dose group 356–542 μg 1.30 (0.78, 2.22)  
Shaw GM et al. (2010) [20] Low-dose group < 293.8 μg 1.45 (0.87, 2.41)  
Middle-dose group 293.8–546.3 μg 1  
High-dose group ≥ 546.4 μg 0.74 (0.41, 1.31)  
Czeizel AE et al. (2015) [25] Low-dose group 3 mg 1.06 (0.78, 1.44) 1.49 (0.65, 3.41)
Middle-dose group 6 mg 1 1
High-dose group 9 mg 1.14 (0.71, 1.81) 1.81 (0.51, 6.42)
Mao B et al. (2017) [34] Low -dose group < 149.88 μg 1.63 (1.01, 2.62) 1.44 (0.72, 2.87)
Middle-dose group 149.88–266.35 μg 1 1
High-dose group ≥ 266.35 μg 1.06 (0.62, 1.81) 1.07 (0.50, 2.25)
  1. FA folic acid, CHD congenital heart disease, ASD atrial septal defects