Table 2 Clinical trials in acute UTI/rUTIs with treatment supplementations including D-mannose and probiotics
From: Role of D-mannose in urinary tract infections – a narrative review
Reference | Study Design | Subjects and groups | Supplementation | Main Findings (including safety) |
|---|---|---|---|---|
Del Popolo 2018 [71] | Pilot study, non-randomized | 68 women and 17 men affected by recurrent symptomatic cystitis. Of those, 33 women and 13 men suffered from neurogenic bladder n = 85 | Acute: 5-days bid 1000 mg of D-mannose, 200 mg of dry willow extract (salicin) (attack phase), followed by 7-days bid with 700 mg of D-mannose plus 50 mg (109 CFU) of L. acidophilus La-14 (maintenance treatment). Long term: The maintenance treatment was repeated for 15 days every month for the next two months. | Combination treatment was effective in acute UTI and as prophylaxis No significant AEs reported |
Milandri 2018 [72] | Single-center, single-arm, uncontrolled observational study | 19–87-year-old female patients who underwent urodynamic invasive procedure n = 100 | Long-term: After invasive surgery, 14-days bid 1000 mg D-mannose, 200 mg H. sabdariffa, and 109 CFU L. plantarum Lp-115 | Risk of bacteriuria and UTI in women could be reduced with the studied product No AEs |
Murina 2020 [73] | Single-center | Premenopausal women aged 18–50 years with an acute UTI and a history of recurrent uncomplicated UTIs n = 55 | After 2 days Fosfomycin (3 g once a day) the following combination treatment: Lactoflorene Cist® including 109 CFU L. paracasei LC11, cranberry extract and 1000 mg D-mannose: Group 1: once a day for 10 days/month for 90 days (n = 19) Group 2: once a day for 90 days (n = 19) Group 3: No treatment (n = 17) | Both treatments efficient and safe as prophylaxis for rUTIs. No AEs |
Vicariotto 2014 [74] | A pilot prospective study | Premenopausal, nonpregnant women diagnosed with acute uncomplicated cystitis n = 33 | Acute: For 30 days 2 doses a day Long-term: after 30 days acute phase, 1 dose a day until day 60 Dose: 2.5 × 109L. plantarum LP01 and 1 billion L. paracasei LPC09 and S. thermophilus ST10, 250 mg of tara gum, 500 mg of a high proanthocyanidins cranberry extract and 250 mg of D-mannose | Significant improvement in the UTI symptoms (dysuria, frequent voiding, urgency, and suprapubic pain) in long-term No AEs mentioned |