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Table 4 Associations of Urinary Iodine Concentration with thyroid autoimmunity (TPOAb/TgAb/TRAb(+)) Stratified by Gestational Week

From: Iodine nutrition status and thyroid autoimmunity during pregnancy: a cross-sectional study of 4635 pregnant women

Urinary iodine

TPOAb/TgAb/TRAb(+)

OR [CI]

p-value

TPOAb/TgAb/TRAb(+) (without previous thyroid disease)

OR [CI]

P-value

Pooled

 Lower (UIC ≤ 100 μg/L)

34.73

1.324 (1.125–1.559)

0.0007

33.81

1.342 (1.127–1.599)

0.0010

 Low (100 μg/L < UIC < 150 μg/L)

32.36

1.184 (0.983–1.425)

0.0747

30.64

1.151 (0.943–1.405)

0.1662

 Adequate (150 μg/L ≤ UIC < 250 μg/L)

28.76

1.00

 

27.64

1.00

 

 More than adequate (250 μg/L ≤ UIC < 500 μg/L)

26.76

0.906 (0.735–1.117)

0.3567

24.53

0.857 (0.684–1.075)

0.1817

 Excessive (UIC ≥ 500 μg/L)

23.46

0.746 (0.506–1.101)

0.1402

22.30

0.740 (0.489–1.120)

0.1544

Early pregnancy

 Lower

35.11

1.364 (1.023–1.819)

0.0392

33.88

1.370 (1.005–1.867)

0.0468

 Low

31.51

1.164 (0.836–1.620)

0.4537

27.24

0.998 (0.691–1.442)

0.9912

 Adequate

28.61

1.00

 

27.40

1.00

 

 More than adequate

25.96

0.885 (0.626–1.250)

0.4911

24.80

0.895 (0.616–1.301)

0.5607

 Excessive

17.19

0.479 (0.235–0.974)

0.0402

14.29

0.391 (0.171–0.893)

0.0260

Middle pregnancy

 Lower

34.49

1.147 (0.894–1.472)

0.2812

33.87

1.153 (0.844–1.503)

0.2938

 Low

32.55

1.045 (0.791–1.379)

0.7581

31.32

1.015 (0.755–1.365)

0.9220

 Adequate

31.38

1.00

 

30.87

1.00

 

 More than adequate

27.78

0.867 (0.627–1.199)

0.3883

24.90

0.727 (0.510–1.035)

0.0767

 Excessive

21.92

0.615 (0.342–1.105)

0.1038

21.74

0.629 (0.343–1.155)

0.1347

Later pregnancy

 Lower

34.65

1.701 (1.213–2.386)

0.0021

33.66

1.811 (1.260–2.640)

0.0013

 Low

33.06

1.512 (1.027–2.226)

0.0363

33.19

1.711 (1.137–2.573)

0.0099

 Adequate

24.13

1.00

 

22.14

1.00

 

 More than adequate

24.68

1.042 (0.661–1.670)

0.8361

23.40

1.122 (0.686–1.837)

0.6460

 Excessive

44.00

2.455 (1.001–5.377)

0.0499

43.48

2.584 (1.071–6.235)

0.0346

  1. Data are odds ratios [confidence intervals]. Binary logistic regression analyses (forward stepwise) were performed. Adjustment for age, educational status, occupation status, family income in the last year, current smoker, current drinker. Urinary iodine concentrations: lower, < 100 μg/L; low, 100 to < 150 μg/L; adequate, 150 to < 250 μg/L; more than adequate, 250 to < 500 μg/L; excessive, ≥500 μg/L. OR Odds ratio, CI Confidence interval