The impact of serum 25-hydroxyvitamin D, calcium, and parathyroid hormone levels on the risk of coronary artery disease in patients with diabetes: a Mendelian randomization study

Table 1 Characteristics of the single-nucleotide polymorphisms associated with serum 25-hydroxyvitamin D, calcium, and parathyroid hormone levels and their associations with coronary artery disease in patients with diabetes

Traits	SNP	Chr	Nearby gene	EA	OA	EAF	25OHD/Calcium/PTH			CAD in patients with diabetes
Traits	SNP	Chr	Nearby gene	EA	OA	EAF	Beta	SE	P	Beta	SE	P
25OHD	rs3755967	4	GC	C	T	0.72	0.089	0.002	4.74E-343	0.032	0.029	0.274
25OHD	rs12785878	11	DHCR7	T	G	0.75	0.036	0.002	3.80E-62	-0.055	0.033	0.090
25OHD	rs10741657	11	CYP2R1	A	G	0.40	0.031	0.002	2.05E-46	-0.001	0.027	0.972
25OHD	rs17216707	20	CYP24A1	T	C	0.79	0.026	0.003	8.14E-23	-0.033	0.035	0.344
25OHD	rs10745742	12	AMDHD1	T	C	0.40	0.017	0.002	1.88E-14	-0.019	0.028	0.495
25OHD	rs8018720	14	SEC23A	G	C	0.18	0.017	0.003	4.72E-09	0.019	0.034	0.586
Calcium	rs1801725	3	CASR	T	G	0.15	0.071	0.004	8.90E-86	0.052	0.039	0.186
Calcium	rs1570669	20	CYP24A1	G	A	0.34	0.018	0.003	9.10E-12	-0.001	0.028	0.981
Calcium	rs1550532	2	DGKD	C	G	0.31	0.018	0.003	8.20E-11	-0.017	0.028	0.545
Calcium	rs7481584	11	CARS	G	A	0.70	0.018	0.003	1.20E-10	-0.004	0.030	0.904
Calcium	rs780094	2	GCKR	T	C	0.42	0.017	0.003	1.30E-10	0.085	0.028	0.002
Calcium	rs7336933	13	DGKH	G	A	0.85	0.022	0.004	9.10E-10	-0.021	0.037	0.568
Calcium	rs10491003	10	GATA3	T	C	0.09	0.027	0.005	4.80E-09	-0.013	0.046	0.784
PTH	rs6127099	20	CYP24A1	T	A	0.34	0.070	0.003	2.40E-72	0.021	0.030	0.494
PTH	rs4074995	5	RGS14	G	A	0.71	0.030	0.003	3.30E-23	0.029	0.030	0.337
PTH	rs219779	21	CLDN14	G	A	0.75	0.040	0.003	8.90E-22	-0.017	0.030	0.582
PTH	rs4443100	22	RTDR1	G	C	0.32	0.020	0.003	4.10E-11	-0.025	0.029	0.390
PTH	rs73186030	3	CASR	T	C	0.14	0.030	0.004	1.20E-09	0.051	0.039	0.198

SNP indicates single-nucleotide polymorphism, Chr chromosome, EA effect allele, OA other allele, EAF effect allele frequency, 25OHD 25-hydroxyvitamin D, PTH parathyroid hormone, CAD coronary artery disease, SE standard error

ISSN: 1475-2891