Table 3 Association analysis of composite gene score of T2D SNPs (IGF2BP2, TCF7L2 and KCNQ1) used as a genetic Instrument for their joint effects on 25(OH)D concentrations
Study | N | Beta | SE | P Val | Z Score | Direction |
|---|---|---|---|---|---|---|
AIDHS/SDS | 2675 | -0.006 | 0.014 | 6.98E-01 | ||
SIKH REPLICATION | 2197 | -0.001 | 0.009 | 8.96E-01 | ||
SOUTH ASIAN META | 4872 | -0.003 | 0.008 | 7.45E-01 | -0.367 | – – |
Twins UK | 5335 | 0.0004 | 0.001 | 7.07E-01 | ||
1958 BC | 5181 | 0.1322 | 0.056 | 1.90E-02 | ||
CCHS/CGPS/CIHDS | 11,665 | -0.0080 | 0.007 | 2.35E-01 | ||
PREVEND | 3649 | -0.0154 | 0.031 | 6.20E-01 | ||
Meta-Analysis | 30,702 | -0.0002 | 0.0001 | 8.29E-01 | -0.212 | – – + + – – |