Table 2 Association analysis of composite gene score of T2D SNPs (IGF2BP2, TCF7L2, and KCNQ1) used as a genetic instrument for their joint effect on T2D
Study | N | OR | LCI | UCI | P Val | Z score | Direction |
|---|---|---|---|---|---|---|---|
AIDHS/SDS | 2675 | 1.42 | 1.33 | 1.52 | 6.09E-13 | ||
SIKH REPLICATION | 2197 | 1.69 | 1.36 | 2.02 | 2.00E-03 | ||
IMS | 848 | 1.27 | 1.04 | 1.51 | 4.62E-02 | ||
SOUTH ASIAN META | 5720 | 1.42 | 1.34 | 1.50 | 1.33E-12 | 7.09 | + + + |
Twins UK | 5335 | 1.18 | 1.00 | 1.35 | 6.84E-02 | ||
1958 BC | 5181 | 1.30 | 1.13 | 1.46 | 1.81E-03 | ||
CCHS/CGPS/CIHDS | 23,029 | 1.24 | 1.22 | 1.26 | 5.70E-15 | ||
UKHLS | 8902 | 1.18 | 1.09 | 1.26 | 1.53E-04 | ||
PREVEND | 3649 | 1.27 | 1.17 | 1.37 | 2.18E-06 | ||
Meta-Analysis | 51,816 | 1.24 | 1.22 | 1.26 | 1.82E-32 | 11.86 | + + + + + + + + |