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Table 1 Clinical and demographic traits of subjects in the participating cohorts stratified by type 2 diabetes

From: A Bidirectional Mendelian Randomization Study to evaluate the causal role of reduced blood vitamin D levels with type 2 diabetes risk in South Asians and Europeans

Study Cohorts

Location

Type 2 Diabetes

N

Female

Age

BMI

25(OH)D

    

%

(yrs)

(kg/m2)

(nmol/L)

South Asian

       

AIDHS/SDS

Punjab, India

Cases

1586

44

54.0±11.1

27.4±4.9

31.2±37.6

STAGE I

 

Controls

1123

46

51.0±14.3

26.5±4.9

46.3±45.5

  

Combined

2709

45

52.8±12.6

27.0±4.9

37.0±41.5

AIDHS/SDS

Punjab, India

Cases

1164

44

55.9±11.9

27.1±4.8

32.8±21.4

STAGE II

 

Controls

1033

44

46.2±14.2

25.8±4.5

34.9±23.8

  

Combined

2197

44

51.4±13.9

26.5±4.7

33.8±22.5

 

Andra Pradesh India

Cases

385

35

44.2±0.5

23.8±0.2

N/A

IMS

 

Controls

485

37

47.5±0.3

26.0±0.2

N/A

  

Combined

870

36

46.0±8.4

25.0±4.2

N/A

Caucasian

       
 

London

Cases

124

100

61.1±9.4

28.1±5.9

76.2±44.9

TWINS UK

UK

Controls

5215

91

52.1±14.5

26.1±4.9

76.4±40.5

  

Combined

5339

91

52.3±14.4

26.1±5.0

76.4±40.6

 

England/Scotland/Wales

Cases

179

41

45*

33.9±6.7

47.4±23.4

1958 Birth Cohort

UK

Controls

5002

50

45*

27.2±4.7

57.9±25.5

  

Combined

5181

50

45*

27.4±4.9

57.6±25.5

 

Copenhagen, Denmark

Cases

1562

44

65.8±10.1

29.5±5.1

47.3±25.0

CCHS/CGPS/ CIHDS

 

Controls

29478

56

59.2±12.9

25.9±4.2

54.1±26.0

  

Combined

31040

55

59.5±12.8

26.1±4.3

53.7±26.0

 

Essex, UK

Cases

496

45

64.9±12.3

31.8±6.1

N/A

UKHLS

 

Controls

8409

57

52.6±16.1

27.9±5.1

N/A

  

Combined

8905

56

53.3±16.2

28.1±5.3

N/A

 

Groningen,

Cases

366

62

56.5±10.1

29.4±4.7

55.1±21.0

PREVEND

Netherland

Controls

3283

50

49.5±12.5

25.8±4.0

59.0±23.7

  

Combined

3649

52

50.2±12.5

26.1±4.3

58.6±23.4

  1. Total 435 sib pairs (870 individuals); 54.8% T2D (N = 870); Out of 435 pairs, 385 pairs are discordant for T2D, and 50 pairs are concordant for T2D
  2. *Please note all participants are at the same age. Information for BMI, blood 25(OH)D were measured from 45 yr. survey, whereas T2D cases/controls were ascertained from 45, 46 and 50 yr. surveys combined
  3. Abbreviations: N/A: Not available, AIDHS/SDS: Asian Indian Diabetic Heart Study/ Sikh Diabetes Study, IMS: Indian Migration Study, CCHS/CGPS/CIHDS: Copenhagen City Heart Study/ Copenhagen General Population Study/ Copenhagen Ischemic Heart Disease Study, UKHLS: UK Household Longitudinal Study, PREVEND: Prevention of Renal and Vascular End-Stage Disease study