Table 3 Difference (day 10 - day 0) and difference-in-difference (DID) in fatty acids levels in the blood of children with severe acute malnutrition in the emollient vs. the control group, by age strata (n = 203 children with both day 10 and day 0 samples, n = 406 samples included in fatty acid analysis)
Fatty acids (μg/mL)1 | 2 to < 6 months group | 6 to 24 months group | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
Difference (day 10 minus day 0), Emollient n = 33 (Median) | Difference (day 10 minus day 0), No emollient n = 32 (Median) | DID (Emollient minus No emollient) | p-value2 | q-value3 | Difference (day 10 minus day 0), Emollient n = 67 (Median) | Difference (day 10 minus day 0), No emollient n = 71 (Median) | DID (Emollient minus No emollient) | p-value2 | q-value3 | |
myristic acid (14:0) | 48.95 | 30.78 | 18.17 | 0.184 | 0.300 | 33.89 | 34.12 | −0.23 | 0.661 | 0.983 |
pentadecanoic acid (15:0) | 5.51 | 3.95 | 1.56 | 0.299 | 0.381 | 3.43 | 3.87 | − 0.44 | 0.591 | 0.983 |
palmitic acid (16:0) | 102.87 | −36.59 | 139.46 | 0.171 | 0.300 | 32.24 | 51.65 | −19.41 | 0.782 | 0.983 |
stearic acid (18:0) | 50.12 | 25.33 | 24.78 | 0.193 | 0.300 | 46.76 | 61.64 | − 14.89 | 0.493 | 0.983 |
arachidic acid (20:0) | 0.85 | 0.52 | 0.33 | 0.318 | 0.387 | 0.88 | 0.86 | 0.02 | 0.939 | 0.983 |
behenic acid (22:0) | 0.51 | 0.12 | 0.39 | 0.049** | 0.294 | 0.68 | 0.74 | −0.06 | 0.730 | 0.983 |
lignoceric acid (24:0) | 0.23 | − 0.07 | 0.30 | 0.087* | 0.297 | 0.11 | 0.11 | 0.01 | 0.757 | 0.983 |
myristoleic acid (14:1n5) | 2.38 | 0.88 | 1.49 | 0.078* | 0.297 | 1.09 | 1.47 | −0.38 | 0.583 | 0.983 |
palmitoleic acid (16:1n7) | −10.91 | −26.67 | 15.75 | 0.063* | 0.294 | −23.01 | −18.77 | −4.24 | 0.775 | 0.983 |
vaccenic acid (18:1n7) | −3.68 | −11.19 | 7.51 | 0.108 | 0.297 | −6.22 | −4.55 | −1.66 | 0.966 | 0.983 |
oleic acid (18:1n9) | 88.68 | − 21.91 | 110.59 | 0.155 | 0.297 | 33.98 | 47.99 | −14.01 | 0.983 | 0.983 |
cis-11-eicosaenoic acid (20:1n9) | 0.70 | −0.35 | 1.06 | 0.662 | 0.713 | 0.40 | 0.32 | 0.08 | 0.759 | 0.983 |
mead acid (20:3n9) | −0.95 | −1.54 | 0.59 | 0.097* | 0.297 | −0.91 | −0.86 | − 0.05 | 0.900 | 0.983 |
erucic acid (22:1n9) | 0.07 | −0.18 | 0.25 | 0.129 | 0.297 | 0.20 | −0.07 | 0.27 | 0.138 | 0.983 |
nervonic acid (24:1n9) | −0.58 | −1.00 | 0.42 | 0.148 | 0.297 | −1.60 | −1.56 | −0.05 | 0.875 | 0.983 |
linoleic acid (18:2n6) | 335.77 | 237.44 | 98.33 | 0.270 | 0.377 | 456.43 | 405.21 | 51.22 | 0.399 | 0.983 |
gamma-linolenic acid (18:3n6) | 2.92 | 0.86 | 2.06 | 0.038** | 0.294 | 3.06 | 3.35 | −0.28 | 0.761 | 0.983 |
cis-11,14-eicosadienoic acid (20:2n6) | 3.15 | 2.96 | 0.20 | 0.502 | 0.585 | 4.68 | 4.38 | 0.30 | 0.597 | 0.983 |
dihomo-gamma-linolenic acid (20:3n6) | 8.53 | 4.00 | 4.53 | 0.117 | 0.297 | 7.87 | 10.68 | −2.81 | 0.307 | 0.983 |
arachidonic acid (20:4n6) | −22.11 | −70.87 | 48.76 | 0.051* | 0.294 | −95.31 | −81.92 | −13.38 | 0.720 | 0.983 |
cis-13-16-docosadienoic acid (22:2n6) | −0.85 | −0.37 | −0.48 | 0.533 | 0.597 | N/A | N/A | N/A | 1.000 | 1.000 |
adrenic acid (22:4n6) | 0.16 | −0.14 | 0.30 | 0.053* | 0.294 | −.08 | −0.07 | −0.01 | 0.723 | 0.983 |
osbond acid (22:5n6) | 0.07 | −1.08 | 1.15 | 0.293 | 0.381 | −2.25 | −2.18 | −0.08 | 0.892 | 0.983 |
alpha-linolenic acid (18:3n3) | 11.53 | 10.78 | 0.75 | 0.809 | 0.839 | 25.52 | 20.47 | 5.05 | 0.389 | 0.983 |
stearidonic acid (18:4n3) | 0.05 | 0.09 | −0.04 | 1.000 | 0.880 | 0.92 | N/A | N/A | 1.000 | 1.000 |
eicosatetraenoic acid (20:4n3) | 0.28 | 0.23 | 0.04 | 0.880 | 0.880 | 0.31 | 0.37 | −0.06 | 0.742 | 0.983 |
eicosapentaenoic acid (20:5n3) | 0.83 | −2.12 | 2.96 | 0.023** | 0.294 | −1.84 | −1.93 | 0.10 | 0.759 | 0.983 |
docosapentaenoic acid (22:5n3) | 1.01 | 0.04 | 0.97 | 0.212 | 0.312 | −1.16 | −1.58 | 0.42 | 0.875 | 0.983 |
docosahexaenoic acid (22:6n3) | −3.61 | −24.89 | 21.29 | 0.159 | 0.297 | −44.91 | −50.73 | 5.82 | 0.517 | 0.983 |