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Table 3 Difference (day 10 - day 0) and difference-in-difference (DID) in fatty acids levels in the blood of children with severe acute malnutrition in the emollient vs. the control group, by age strata (n = 203 children with both day 10 and day 0 samples, n = 406 samples included in fatty acid analysis)

From: Effect of topical applications of sunflower seed oil on systemic fatty acid levels in under-two children under rehabilitation for severe acute malnutrition in Bangladesh: a randomized controlled trial

Fatty acids
(μg/mL)1
2 to < 6 months group 6 to 24 months group
Difference (day 10 minus day 0), Emollient n = 33 (Median) Difference (day 10 minus day 0), No emollient n = 32 (Median) DID (Emollient minus No emollient) p-value2 q-value3 Difference (day 10 minus day 0), Emollient n = 67 (Median) Difference (day 10 minus day 0), No emollient n = 71 (Median) DID (Emollient minus No emollient) p-value2 q-value3
myristic acid (14:0) 48.95 30.78 18.17 0.184 0.300 33.89 34.12 −0.23 0.661 0.983
pentadecanoic acid (15:0) 5.51 3.95 1.56 0.299 0.381 3.43 3.87 − 0.44 0.591 0.983
palmitic acid (16:0) 102.87 −36.59 139.46 0.171 0.300 32.24 51.65 −19.41 0.782 0.983
stearic acid (18:0) 50.12 25.33 24.78 0.193 0.300 46.76 61.64 − 14.89 0.493 0.983
arachidic acid (20:0) 0.85 0.52 0.33 0.318 0.387 0.88 0.86 0.02 0.939 0.983
behenic acid (22:0) 0.51 0.12 0.39 0.049** 0.294 0.68 0.74 −0.06 0.730 0.983
lignoceric acid (24:0) 0.23 − 0.07 0.30 0.087* 0.297 0.11 0.11 0.01 0.757 0.983
myristoleic acid (14:1n5) 2.38 0.88 1.49 0.078* 0.297 1.09 1.47 −0.38 0.583 0.983
palmitoleic acid (16:1n7) −10.91 −26.67 15.75 0.063* 0.294 −23.01 −18.77 −4.24 0.775 0.983
vaccenic acid (18:1n7) −3.68 −11.19 7.51 0.108 0.297 −6.22 −4.55 −1.66 0.966 0.983
oleic acid (18:1n9) 88.68 − 21.91 110.59 0.155 0.297 33.98 47.99 −14.01 0.983 0.983
cis-11-eicosaenoic acid (20:1n9) 0.70 −0.35 1.06 0.662 0.713 0.40 0.32 0.08 0.759 0.983
mead acid (20:3n9) −0.95 −1.54 0.59 0.097* 0.297 −0.91 −0.86 − 0.05 0.900 0.983
erucic acid (22:1n9) 0.07 −0.18 0.25 0.129 0.297 0.20 −0.07 0.27 0.138 0.983
nervonic acid (24:1n9) −0.58 −1.00 0.42 0.148 0.297 −1.60 −1.56 −0.05 0.875 0.983
linoleic acid (18:2n6) 335.77 237.44 98.33 0.270 0.377 456.43 405.21 51.22 0.399 0.983
gamma-linolenic acid (18:3n6) 2.92 0.86 2.06 0.038** 0.294 3.06 3.35 −0.28 0.761 0.983
cis-11,14-eicosadienoic acid (20:2n6) 3.15 2.96 0.20 0.502 0.585 4.68 4.38 0.30 0.597 0.983
dihomo-gamma-linolenic acid (20:3n6) 8.53 4.00 4.53 0.117 0.297 7.87 10.68 −2.81 0.307 0.983
arachidonic acid (20:4n6) −22.11 −70.87 48.76 0.051* 0.294 −95.31 −81.92 −13.38 0.720 0.983
cis-13-16-docosadienoic acid (22:2n6) −0.85 −0.37 −0.48 0.533 0.597 N/A N/A N/A 1.000 1.000
adrenic acid (22:4n6) 0.16 −0.14 0.30 0.053* 0.294 −.08 −0.07 −0.01 0.723 0.983
osbond acid (22:5n6) 0.07 −1.08 1.15 0.293 0.381 −2.25 −2.18 −0.08 0.892 0.983
alpha-linolenic acid (18:3n3) 11.53 10.78 0.75 0.809 0.839 25.52 20.47 5.05 0.389 0.983
stearidonic acid (18:4n3) 0.05 0.09 −0.04 1.000 0.880 0.92 N/A N/A 1.000 1.000
eicosatetraenoic acid (20:4n3) 0.28 0.23 0.04 0.880 0.880 0.31 0.37 −0.06 0.742 0.983
eicosapentaenoic acid (20:5n3) 0.83 −2.12 2.96 0.023** 0.294 −1.84 −1.93 0.10 0.759 0.983
docosapentaenoic acid (22:5n3) 1.01 0.04 0.97 0.212 0.312 −1.16 −1.58 0.42 0.875 0.983
docosahexaenoic acid (22:6n3) −3.61 −24.89 21.29 0.159 0.297 −44.91 −50.73 5.82 0.517 0.983
  1. 1See Supplemental Table 10 for summary day 0 and day 10 FA concentrations and measures of variance
  2. 2Mann–Whitney U test, ** = p < 0.05, * = P < 0.1
  3. 3p-values adjusted for multiple hypothesis testing using the Benjamini Hochberg false discovery rate controlling procedure [55]