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Table 3 Effect of probiotics supplementation on metabolic endotoxemia and inflammation markers

From: Effect of probiotic supplementation along with calorie restriction on metabolic endotoxemia, and inflammation markers in coronary artery disease patients: a double blind placebo controlled randomized clinical trial

Variable

Probiotic group (n = 22)

Placebo group (n = 22)

P-value

IL-10 (ng/dl)

 Baseline

5.11 ± 4.60

4.76 ± 3.60

0.35 (− 2.4 to 2.7), 0.930**

 End

5.14 ± 2.91

5.78 ± 2.29

0.56 (− 2.6 to 1.6), 0.605***

MD (95% CI), P*

0.60 (− 1.4, 2.6) 0.542

1.04 (− 1.31, 3.59) 0.399

 

IL1-Beta (pg/mL)

 Baseline

5.62 ± 3.72

5.31 ± 2.09

−0.31 (− 1.4 to 2.6), 0.723**

 End

3.75 ± 2.10

5.81 ± 3.60

2.05 (− 3.8 to − 0.25), 0.027***

MD (95% CI), P*

− 1.88 (− 3.25, − 0.48) 0.010

0.50 (− 1.58, 2.56) 0.546

 

LPS (ng/ml)

 Baseline

21.92 (11.64)

26.18 (16.85)

4.25 (−13.1, 4.4), 0.335**

 End

16.04 (6.8)

23.22 (12.22)

7.27 (−13.4, − 1.4), 0.016***

MD (95% CI), P*

−5.88 (− 10.74, − 1.09), 0.019

− 2.96 (− 11.6, 5.7), 0.165

 

TLR4 (ng/ml)

 Baseline

11.59 (7.22)

10.58 (8.30)

1.01 (− 2.4, 5.6), 0.765**

 End

9.8 (7.24)

11.85 (5.6)

2.2 (−5.3, 1.8), 0.301***

MD (95% CI), P*

−1.79 (−6.21, 3.10), 0.488

1.27 (− 1.7, 4.7), 0.581

 
  1. LPS Lipopolysaccharide, Mean (SD) and Mean difference (95% CI) are presented for data
  2. * P based on Paired samples t-test
  3. ** P based on Independent samples t-test
  4. *** P based on ANCOVA adjusted for baseline values, weight, PAL, and calorie intakes