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Table 6 Modelled estimates of differences in apolipoprotein, lipoproteins and lipids between intervention and controla

From: Diet intervention improves cardiovascular profile in patients with rheumatoid arthritis: results from the randomized controlled cross-over trial ADIRA

 

Intervention

(n = 42)

Mean Change (95% CIs)

Control

(n = 43)

Mean Change (95% CIs)

Difference

between dietary periodsb

95% CIs

P

Apolipoprotein concentrations (mg/dL)

 Apo-A1

2.782 (− 1.491, 7.054)

1.111 (− 3.104, 5.327)

1.670

− 3.505, 6.846

0.517

 Apo-B100

− 0.325 (− 3.758, 3.108)

4.130 (0.741, 7.520)

− 4.455

−8.331, − 0.578

0.026

 Apo-B100/Apo-A1

− 0.016 (− 0.039, 0.007)

0.022 (0.000, 0.045)

− 0.038

− 0.066, − 0.011

0.007

Particle numbers (nmol/L)

 VLDL

−5.750 (− 15.270, 3.771)

4.835 (− 4.535, 14.205)

− 10.585

− 23.951, 2.782

0.119

 IDL

−2.813 (− 9.383, 3.757)

7.429 (0.958, 13.899)

− 10.241

− 18.699, − 1.783

0.019

 LDL

7.210 (− 53.413, 67.833)

62.424 (2.563, 122.285)

−55.214

−123.396, 12.968

0.109

Triglycerides in lipoprotein particles (mg/dL)

 VLDL

−11.762 (− 19.999, −3.526)

5.072 (− 3.038, 13.182)

− 16.834

−28.404, − 5.264

0.005

 IDL

−2.022 (− 3.448, − 0.595)

1.068 (− 0.337, 2.473)

−3.090

−5.092, − 1.088

0.003

 LDL

0.054 (− 0.840, 0.949)

0.870 (− 0.011, 1.750)

− 0.815

− 1.976, 0.345

0.163

 HDL

−0.171 (− 0.726, 0.385)

0.586 (0.039, 1.133)

− 0.757

− 1.530, 0.016

0.055

Cholesterol in HDL particles (mg/dL)

 HDL-1

2.461 (0.922, 4.001)

−0.625 (− 2.145, 0.894)

3.087

1.303, 4.871

0.001

 HDL-2

0.327 (−0.086, 0.741)

−0.181 (− 0.590, 0.227)

0.509

0.063, 0.955

0.027

 HDL-3

0.045 (−0.339, 0.430)

−0.012 (− 0.390, 0.367)

0.057

−0.459, 0.573

0.824

 HDL-4

−0.223 (− 0.976, 0.530)

0.282 (− 0.459, 1.023)

−0.505

−1.524, 0.513

0.320

  1. aParticipants completing at least one dietary period and with coherent results between clinical data and NMR-analysis (n = 44), analyzed by use of a linear mixed model with period, treatment, sequence and baseline value as fixed effects and subject as random effect adjusted for sex. Apo-A1, Apolipoprotein A1; Apo-B100, Apolipoprotein B100; VLDL, Very low density lipoprotein; IDL, Intermediate density lipoprotein; LDL, low density lipoprotein, HDL, High density lipoprotein; HDL-1, 1.063–1.100 kg/L; HDL-2, 1.100–1.112 kg/L; HDL-3, 1.112–1.125 kg/L; HDL-4, 1.125–1.210 kg/L
  2. bIntervention – Control, post period values