Skip to main content

Table 2 Relationship between chitosan and glucose based on subgroup analysis

From: Chitosan modifies glycemic levels in people with metabolic syndrome and related disorders: meta-analysis with trial sequential analysis

Variable Chitosan group (n)/Control group (n) No. of treatment arms Pooled SMD(mmol/L) 95% CI Z-value P-value I-squared (%)
subgroups
Dose of chitosan (g/d)
  < 1.6 137/135 4 −0.29 −0.51 - -0.07 2.62 0.009 86.60
  1.6–3 336/332 8 −0.42 − 0.57 - -0.26 5.28 0.000 74.20
  ≥3 151/151 2 −0.16 −0.39- 0.06 1.40 0.160 0.00
Intervention duration (weeks)
  > 13 315/310 5 −0.48 −0.64 - -0.32 5.90 0.000 81.20
  ≤ 13 341/343 9 −0.18 −0.33 - -0.03 2.35 0.019 67.40
Study design
  Parallel 460/460 10 −0.35 −0.48 - -0.22 5.20 0.000 70.10
  Crossover 196/193 4 −0.27 −0.47 - -0.06 2.58 0.010 86.60
Age
  < 50 516/507 9 −0.34 −0.48 - -0.02 2.10 0.036 81.80
  ≥ 50 140/146 4 −0.25 −0.47 - -0.22 5.42 0.000 0.70
Study population
  Diabetes 94/95 3 −0.66 −0.96 - -0.36 4.29 0.000 87.40
  Overweight/Obese 320/314 6 −0.39 −0.55 - -0.24 4.86 0.000 80.00
  Dyslipidemia 242/244 5 −0.12 − 0.30 - 0.06 1.31 0.189 0.00