Table 4 Association between dietary flavonoids intake and cancer mortality

  No. of deaths

186

223

235

243

265

  Age-adjusted HR (95% CI) ^a

1

1.22 (1.00–1.48)

1.27 (1.05–1.54)

1.27 (1.05–1.54)

1.43 (1.19–1.73)

  Multivariate-adjusted HR (95% CI) ^b

1

1.18 (0.97–1.44)

1.17 (0.96–1.42)

1.13 (0.93–1.38)

1.19 (0.97–1.44)

   < 60 years

  HR (95% CI) ^b

1

1.03 (0.79–1.35)

1.07 (0.82–1.38)

1.11 (0.85–1.44)

1.04 (0.80–1.35)

   > 60 years

  HR (95% CI) ^b

1

1.36 (1.01–1.82)

1.19 (0.89–1.60)

1.08 (0.80–1.46)

1.23 (0.91–1.65)

   < 30

  HR (95% CI) ^b

1

1.08 (0.85–1.35)

1.12 (0.90–1.38)

1.11 (0.89–1.37)

1.13 (0.91–1.40)

   > 30

  HR (95% CI) ^b

1

1.66 (1.07–3.79)

1.41 (0.88–2.23)

1.14 (0.70–1.97)

1.28 (0.78–2.11)

  No. of deaths

108

123

123

145

143

  Age-adjusted HR (95% CI) ^a

1

1.17 (0.90–1.52)

1.16 (0.90–1.51)

1.32 (1.02–1.69)

1.35 (1.05–1.73)

  Multivariate-adjusted HR (95% CI) ^b

1

1.12 (0.86–1.45)

1.02 (0.78–1.32)

1.11 (0.86–1.44)

1.04 (0.80–1.35)

   < 60 years

  HR (95% CI) ^b

1

0.85 (0.59–1.24)

0.97 (0.68–1.38)

1.04 (0.73–1.48)

0.80 (0.55–1.15)

   > 60 years

  HR (95% CI) ^b

1

1.41 (0.98–2.04)

0.96 (0.65–1.42)

1.09 (0.75–1.59)

1.20 (0.82–1.74)

   < 30

  HR (95% CI) ^b

1

1.00 (0.85–1.35)

0.97 (0.73–1.28)

1.06 (0.81–1.40)

0.99 (0.74–1.31)

   > 30

  HR (95% CI) ^b

1

2.01 (1.06–3.79)

1.36 (0.68–2.71)

1.35 (0.67–2.70)

1.26 (0.61–2.60)

  No. of deaths

78

100

112

98

122

  Age-adjusted HR (95% CI) ^a

1

1.28 (0.95–1.73)

1.42 (1.07–1.90)

1.21 (0.90–1.63)

1.55 (1.17–2.07)

  Multivariate-adjusted HR (95% CI) ^b

1

1.27 (0.99–1.71)

1.38 (1.03–1.85)

1.14 (0.84–1.55)

1.39 (1.53–1.88)

   < 60 years

  HR (95% CI) ^b

1

1.25 (0.85–1.83)

1.78 (0.80–1.73)

1.17 (0.79–1.73)

1.36 (0.93–2.00)

   > 60 years

  HR (95% CI) ^b

1

1.27 (0.78–2.05)

1.58 (1.00–2.49)

1.05 (0.63–1.71)

1.27 (0.78–2.06)

   < 30

  HR (95% CI) ^b

1

1.22 (0.87–1.72)

1.35 (0.97–1.88)

1.17 (0.83–1.64)

1.36 (0.97–1.90)

   > 30

  HR (95% CI) ^b

1

1.40 (0.75–2.59)

1.44 (0.77–2.69)

0.96 (0.48–1.93)

1.32 (0.67–2.61)

  No. of deaths

186

226

223

253

265

  Age-adjusted HR (95% CI) ^a

1

1.23 (1.01–1.49)

1.99 (0.98–1.45)

1.31 (1.08–1.58)

1.42 (1.18–1.71)

  Multivariate-adjusted HR (95% CI) ^b

1

1.21 (0.99–1.47)

1.11 (0.91–1.36)

1.17 (0.96–1.42)

1.19 (0.97–1.45)

   < 60 years

  HR (95% CI) ^b

1

0.97 (0.74–1.26)

0.98 (0.76–1.28)

1.12 (0.87–1.44)

0.96 (0.74–1.26)

   > 60 years

  HR (95% CI) ^b

1

1.54 (1.15–2.07)

1.21 (0.89–1.64)

1.15 (0.85–1.55)

1.35 (1.00–1.83)

   < 30

  HR (95% CI) ^b

1

1.15 (0.75–1.34)

1.04 (0.83–1.29)

1.17 (0.94–1.45)

1.15 (0.93–1.43)

   > 30

  HR (95% CI) ^b

1

1.46 (0.93–2.27)

1.48 (0.94–2.31)

1.04 (0.63–1.71)

1.16 (0.70–1.91)

  No. of deaths

109

120

120

151

143

  Age-adjusted HR (95% CI) ^a

1

1.12 (0.87–1.46)

1.11 (0.86–1.44)

1.34 (1.05–1.71)

1.32 (1.03–1.70)

  Multivariate-adjusted HR (95% CI) ^b

1

1.10 (0.76–1.29)

0.99 (0.76–1.29)

1.14 (0.88–1.47)

1.03 (0.79–1.35)

   < 60 years

  HR (95% CI) ^b

1

0.77 (0.53–1.11)

0.88 (0.60–1.23)

1.10 (0.79–1.54)

0.69 (0.48–1.00)

   > 60 years

  HR (95% CI) ^b

1

1.54 (1.06)

1.10 (0.74–1.63)

1.07 (0.74–1.58)

1.38 (0.94–2.02)

   < 30

  HR (95% CI) ^b

1

1.00 (0.75–1.34)

0.92 (0.69–1.23)

1.13 (0.86–1.49)

1.01 (0.76–1.34)

   > 30

  HR (95% CI) ^b

1

1.74 (0.93–3.27)

1.51 (0.79–2.89)

1.06 (0.52–2.16)

1.04 (0.50–2.15)

  No. of deaths

77

106

103

102

122

  Age-adjusted HR (95% CI) ^a

1

1.37 (1.02–1.84)

1.31 (0.98–1.77)

1.26 (0.94–1.70)

1.56 (1.17–2.08)

  Multivariate-adjusted HR (95% CI) ^b

1

1.37 (1.01–1.84)

1.28 (0.95–1.72)

1.20 (0.88–1.62)

1.40 (1.04–1.90)

   < 60 years

  HR (95% CI) ^b

1

1.23 (0.84–1.80)

1.15 (0.78–1.68)

1.11 (0.75–1.64)

1.35 (0.92–1.97)

   > 60 years

  HR (95% CI) ^b

1

1.56 (0.97–2.51)

1.40 (0.86–2.27)

1.27 (0.78–2.07)

1.31 (0.80–2.16)

   < 30

  HR (95% CI) ^b

1

1.39 (0.99–1.95)

1.23 (0.87–1.73)

1.22 (0.86–1.71)

1.38 (0.98–1.94)

   > 30

  HR (95% CI) ^b

1

1.23 (0.65–2.30)

1.43 (0.77–2.66)

1.03 (0.51–2.05)

1.30 (0.65–2.59)

  No. of deaths

186

218

234

246

269

  Age-adjusted HR (95% CI) ^a

1

1.17 (0.96–1.42)

1.27 (1.05–1.54)

1.26 (1.04–1.52)

1.44 (1.19–1.73)

  Multivariate-adjusted HR (95% CI) ^b

1

1.40 (0.93–1.39)

1.16 (0.95–1.41)

1.12 (0.92–1.36)

1.19 (0.98–1.44)

   < 60 years

  HR (95% CI) ^b

1

1.01 (0.77–1.320

1.08 (0.83–1.39)

1.07 (0.82–1.38)

1.04 (0.80–1.35)

   > 60 years

  HR (95% CI) ^b

1

1.30 (0.97–1.75)

1.15 (0.85–1.55)

1.12 (0.83–1.50)

1.23 (0.92–1.66)

   < 30

  HR (95% CI) ^b

1

1.02 (0.82–1.28)

1.08 (0.87–1.33)

1.09 (0.88–1.34)

1.11 (0.90–1.38)

   > 30

  HR (95% CI) ^b

1

1.73 (1.11–2.71)

1.58 (0.99–2.51)

1.18 (0.71–1.94)

1.40 (0.85–2.30)

  No. of deaths

108

115

127

148

145

  Age-adjusted HR (95% CI) ^a

1

1.07 (0.82–1.39)

1.21 (0.83–1.56)

1.31 (1.02–1.68)

1.35 (1.05–1.73)

  Multivariate-adjusted HR (95% CI) ^b

1

1.03 (0.79–1.34)

1.04 (0.80–1.35)

1.11 (0.86–1.43)

1.03 (0.80–1.34)

   < 60 years

  HR (95% CI) ^b

1

0.78 (0.53–1.14)

0.99 (0.70–1.40)

1.02 (0.72–1.44)

0.79 (0.55–1.14)

   > 60 years

  HR (95% CI) ^b

1

1.34 (0.92–1.95)

0.98 (0.67–1.45)

1.13 (0.78–1.64)

0.63 (0.83–1.75)

   < 30

  HR (95% CI) ^b

1

0.91 (0.68–1.21)

0.95 (0.72–1.26)

1.05 (0.80–1.38)

0.96 (0.73–1.27)

   > 30

  HR (95% CI) ^b

1

1.98 (1.03–3.80)

1.67 (0.84–3.30)

1.41 (0.69–2.87)

1.42 (0.69–2.94)

  No. of deaths

78

103

107

98

124

  Age-adjusted HR (95% CI) ^a

1

1.31 (0.97–1.75)

1.36 (1.02–1.83)

1.19 (0.88–1.60)

1.57 (1.18–2.08)

  Multivariate-adjusted HR (95% CI) ^b

1

1.29 (0.96–1.74)

1.32 (0.96–1.74)

1.12 (0.83–1.52)

1.40 (1.04–1.89)

   < 60 years

  HR (95% CI) ^b

1

1.30 (0.88–1.90)

1.18 (0.80–1.73)

1.10 (0.75–1.64)

1.37 (0.94–2.01)

   > 60 years

  HR (95% CI) ^b

1

1.29 (0.78–2.02)

1.43 (0.90–2.27)

1.09 (0.68–1.77)

1.28 (0.79–2.07)

   < 30

  HR (95% CI) ^b

1

1.21 (0.86–1.70)

1.27 (0.91–1.77)

1.13 (0.81–2.59)

1.35 (0.97–1.89)

   > 30

  HR (95% CI) ^b

1

1.55 (0.84–2.87)

1.50 (0.79–2.82)

0.97 (0.47–1.99)

1.39 (0.70–2.77)

  No. of deaths

287

238

231

196

200

  Age-adjusted HR (95% CI) ^a

1

0.88 (0.74–1.00)

0.89 (0.74–1.06)

0.77 (0.64–0.92)

0.80 (0.66–0.95)

  Multivariate-adjusted HR (95% CI) ^b

1

0.87 (0.73–1.04)

0.88 (0.74–1.05)

0.78 (0.65–0.94)

0.85 (0.70–1.03)

   < 60 years

  HR (95% CI) ^b

1

0.81 (0.64–1.04)

0.90 (0.71–1.14)

0.86 (0.67–1.10)

0.89 (0.69–1.16)

   > 60 years

  HR (95% CI) ^b

1

0.93 (0.73–1.20)

0.88 (0.68–1.15)

0.74 (0.55–0.99)

0.85 (0.63–1.14)

   < 30

  HR (95% CI) ^b

1

0.92 (0.76–1.10)

0.91 (0.75–1.10)

0.79 (0.64–0.98)

0.88 (0.71–1.09)

   > 30

  HR (95% CI) ^b

1

0.55 (0.34–0.88)

0.64 (0.42–1.00)

0.58 (0.38–0.91)

0.55 (0.35–0.86)

  No. of deaths

154

148

132

109

99

  Age-adjusted HR (95% CI) ^a

1

1.04 (0.83–1.30)

0.96 (0.76–1.22)

0.81 (0.64–1.04)

0.75 (0.58–0.97)

  Multivariate-adjusted HR (95% CI) ^b

1

1.02 (0.81–1.28)

0.96 (0.76–1.22)

0.84 (0.65–1.08)

0.85 (0.65–1.11)

   < 60 years

  HR (95% CI) ^b

1

0.83 (0.59–1.18)

1.08 (0.78–1.50)

0.88 (0.62–1.26)

0.96 (0.66–1.39)

   > 60 years

  HR (95% CI) ^b

1

1.22 (0.90–1.66)

0.85 (0.60–1.21)

0.84 (0.58–1.22)

0.72 (0.51–1.13)

   < 30

  HR (95% CI) ^b

1

1.05 (0.83–1.34)

0.91 (0.70–1.17)

0.79 (0.59–1.04)

0.80 (0.60–1.08)

   > 30

  HR (95% CI) ^b

1

0.61 (0.28–1.33)

1.07 (0.56–2.04)

0.88 (0.46–1.71)

0.80 (0.40–1.60)

  No. of deaths

133

90

99

87

101

  Age-adjusted HR (95% CI) ^a

1

0.71 (0.54–0.93)

0.80 (0.62–1.04)

0.72 (0.55–0.95)

0.84 (0.65–1.09)

  Multivariate-adjusted HR (95% CI) ^b

1

0.70 (0.53–0.91)

0.79 (0.61–1.04)

0.72 (0.55–0.96)

0.83 (0.63–1.11)

   < 60 years

  HR (95% CI) ^b

1

0.79 (0.56–1.12)

0.73 (0.51–1.04)

0.84 (0.59–1.19)

0.82 (0.56–1.19)

   > 60 years

  HR (95% CI) ^b

1

0.54 (0.34–0.85)

0.92 (0.62–1.38)

0.60 (0.38–0.97)

0.96 (0.62–1.48)

   < 30

  HR (95% CI) ^b

1

0.73 (0.54–0.99)

0.91 (0.68–1.22)

0.81 (0.59–1.11)

0.97 (0.71–1.33)

   > 30

  HR (95% CI) ^b

1

0.51 (0.28–0.93)

0.39 (0.21–0.74)

0.41 (0.22–0.76)

0.41 (0.22–0.76)

  No. of deaths

285

225

225

199

219

  Age-adjusted HR (95% CI) ^a

1

0.84 (0.71–1.00)

0.88 (0.74–1.05)

0.77 (0.65–0.93)

0.86 (0.72–1.03)

  Multivariate-adjusted HR (95% CI) ^b

1

0.82 (0.69–0.98)

0.84 (0.70–1.01)

0.74 (0.61–0.90)

0.85 (0.70–1.04)

   < 60 years

  HR (95% CI) ^b

1

0.86 (0.67–1.09)

0.81 (0.63–1.04)

0.73 (0.56–0.94)

0.81 (0.62–1.06)

   > 60 years

  HR (95% CI) ^b

1

0.76 (0.58–0.99)

0.87 (0.67–1.14)

0.76 (0.57–1.02)

0.95 (0.71–1.27)

   < 30

  HR (95% CI) ^b

1

0.83 (0.69–1.01)

0.90 (0.74–1.10)

0.71 (0.57–0.88)

0.90 (0.72–1.12)

   > 30

  HR (95% CI) ^b

1

0.74 (0.47–1.16)

0.54 (0.33–0.87)

0.76 (0.49–1.18)

0.58 (0.36–0.93)

  No. of deaths

159

130

125

116

113

  Age-adjusted HR (95% CI) ^a

1

0.89 (0.70–1.12)

0.90 (0.71–1.14)

0.83 (0.65–1.06)

0.82 (0.64(−1.05)

  Multivariate-adjusted HR (95% CI) ^b

1

0.86 (0.68–1.09)

0.85 (0.66–1.08)

0.79 (0.61–1.02)

0.84 (0.64–1.10)

   < 60 years

  HR (95% CI) ^b

1

0.94 (0.67–1.31)

0.78 (0.55–1.11)

0.73 (0.51–1.06)

0.79 (0.54–1.16)

   > 60 years

  HR (95% CI) ^b

1

0.76 (0.54–1.08)

0.92 (0.65–1.29)

0.85 (0.59–1.22)

0.90 (0.61–1.32)

   < 30

  HR (95% CI) ^b

1

0.85 (0.66–1.09)

0.90 (0.69–1.16)

0.76 (0.57–1.01)

0.86 (0.64–1.16)

   > 30

  HR (95% CI) ^b

1

0.91 (0.48–1.71)

0.56 (0.28–1.14)

0.81 (0.43–1.53)

0.59 (0.30–1.17)

  No. of deaths

126

95

100

83

106

  Age-adjusted HR (95% CI) ^a

1

0.79 (0.60–1.03)

0.86 (0.66–1.12)

0.70 (0.53–0.93)

0.91 (0.70–1.19)

  Multivariate-adjusted HR (95% CI) ^b

1

0.77 (0.59–1.02)

0.83 (0.63–1.09)

0.68 (0.50–0.91)

0.86 (0.64–1.16)

   < 60 years

  HR (95% CI) ^b

1

0.78 (0.54–1.11)

0.84 (0.59–1.19)

0.71 (0.49–1.04)

0.82 (0.56–1.21)

   > 60 years

  HR (95% CI) ^b

1

0.75 (0.49–1.15)

0.80 (0.52–1.25)

0.63 (0.39–1.03)

1.02 (0.65–1.60)

   < 30

  HR (95% CI) ^b

1

0.82 (0.61–1.11)

0.92 (0.68–1.24)

0.64 (0.46–0.90)

0.95 (0.68–1.31)

   > 30

  HR (95% CI) ^b

1

0.59 (0.31–1.13)

0.52 (0.26–1.00)

0.73 (0.40–1.33)

0.57 (0.30–1.11)

  No. of deaths

287

272

208

196

190

  Age-adjusted HR (95% CI) ^a

1

0.99 (0.84–1.17)

0.79 (0.66–0.94)

0.78 (0.65–0.93)

0.77 (0.64–0.93)

  Multivariate-adjusted HR (95% CI) ^b

1

0.96 (0.81–1.14)

0.77 (0.64–0.93)

0.79 (0.66–0.96)

0.82 (0.68–0.98)

   < 60 years

  HR (95% CI) ^b

1

0.97 (0.77–1.22)

0.72 (0.56–0.92)

0.76 (0.59–0.97)

0.73 (0.56–0.94)

   > 60 years

  HR (95% CI) ^b

1

0.93 (0.72–1.19)

0.83 (0.63–1.08)

0.81 (0.61–1.08)

0.90 (0.67–1.19)

   < 30

  HR (95% CI) ^b

1

0.99 (0.83–1.19)

0.81 (0.66–0.99)

0.81 (0.66–1.00)

0.85 (0.65–1.05)

   > 30

  HR (95% CI) ^b

1

0.72 (0.47–1.10)

0.55 (0.35–0.86)

0.60 (0.39–0.94)

0.60 (0.38–0.95)

  No. of deaths

159

162

126

103

93

  Age-adjusted HR (95% CI) ^a

1

1.08 (0.87–1.34)

0.88 (0.69–1.11)

0.76 (0.59–0.97)

0.70 (0.54–0.91)

  Multivariate-adjusted HR (95% CI) ^b

1

1.03 (0.83–1.29)

0.87 (0.69–1.11)

0.81 (0.63–1.04)

0.80 (0.61–1.04)

   < 60 years

  HR (95% CI) ^b

1

1.03 (0.76–1.40)

0.72 (0.51–1.02)

0.74 (0.52–1.05)

0.64 (0.44–0.93)

   > 60 years

  HR (95% CI) ^b

1

1.02 (0.74–1.04)

1.01 (0.72–1.41)

0.84 (0.58–1.22)

0.96 (0.66–1.39)

   < 30

  HR (95% CI) ^b

1

1.07 (0.84–1.36)

0.92 (0.71–1.19)

0.84 (0.63–1.11)

0.86 (0.65–1.15)

   > 30

  HR (95% CI) ^b

1

0.74 (0.41–1.32)

0.55 (0.30–1.02)

0.54 (0.29–1.01)

0.46 (0.23–0.92)

  No. of deaths

128

110

82

93

97

  Age-adjusted HR (95% CI) ^a

1

0.88 (0.68–1.14)

0.68 (0.51–0.89)

0.80 (0.61–1.04)

0.86 (0.66–1.12)

  Multivariate-adjusted HR (95% CI) ^b

1

0.87 (0.67–1.12)

0.66 (0.49–0.88)

0.58 (0.58–1.01)

0.63 (0.63–1.10)

   < 60 years

  HR (95% CI) ^b

1

0.90 (0.64–1.27)

0.71 (0.49–1.03)

0.77 (0.54–1.11)

0.81 (0.57–1.16)

   > 60 years

  HR (95% CI) ^b

1

0.81 (0.54–1.21)

0.58 (0.37–0.91)

0.77 (0.49–1.19)

0.81 (0.52–1.25)

   < 30

  HR (95% CI) ^b

1

0.89 (0.67–1.19)

0.68 (0.49–0.93)

0.77 (0.56–1.05)

0.84 (0.61–1.13)

   > 30

  HR (95% CI) ^b

1

0.70 (0.37–1.30)

0.55 (0.29–1.06)

0.68 (0.37–1.26)

0.76 (0.40–1.42)

  No. of deaths

202

210

237

247

257

  Age-adjusted HR (95% CI) ^a

1

1.07 (0.88–1.30)

1.20 (0.99–1.45)

1.22 (1.01–1.47)

1.31 (1.09–1.58)

  Multivariate-adjusted HR (95% CI) ^b

1

1.05 (0.86–1.27)

1.13 (0.93–1.36)

1.09 (0.90–1.32)

1.12 (0.92–1.36)

   < 60 years

  HR (95% CI) ^b

1

0.89 (0.68–1.16)

1.03 (0.80–1.33)

1.01 (0.78–1.30)

1.00 (0.77–1.30)

   > 60 years

  HR (95% CI) ^b

1

1.20 (0.90–1.60)

1.15 (0.87–1.54)

1.09 (0.81–1.45)

1.11 (0.83–1.50)

   < 30

  HR (95% CI) ^b

1

1.02 (0.82–1.27)

1.09 (0.88–1.35)

1.09 (0.88–1.35)

1.10 (0.89–1.21)

   > 30

  HR (95% CI) ^b

1

1.00 (0.62–1.62)

1.17 (0.74–1.87)

1.26 (0.80–1.99)

0.99 (0.62–1.60)

  No. of deaths

121

111

127

151

133

  Age-adjusted HR (95% CI) ^a

1

0.96 (0.74–1.24)

1.09 (0.85–1.40)

1.26 (0.99–1.61)

1.15 (0.90–1.47)

  Multivariate-adjusted HR (95% CI) ^b

1

0.93 (0.72–1.21)

0.99 (0.77–1.28)

1.06 (0.83–1.36)

0.93 (0.72–1.21)

   < 60 years

  HR (95% CI) ^b

1

0.76 (0.53–1.10)

0.96 (0.68–1.36)

0.94 (0.67–1.33)

0.73 (0.50–1.05)

   > 60 years

  HR (95% CI) ^b

1

1.08 (0.75–1.55)

0.93 (0.64–1.35)

1.08 (0.76–1.55)

1.04 (0.72–1.51)

   < 30

  HR (95% CI) ^b

1

0.88 (0.66–1.17)

0.96 (0.73–1.27)

1.04 (0.80–1.36)

0.92 (0.69–1.21)

   > 30

  HR (95% CI) ^b

1

1.69 (0.58–2.34)

1.51 (0.77–2.94)

1.35 (0.69–2.65)

1.37 (0.70–2.66)

  No. of deaths

81

99

110

96

124

  Age-adjusted HR (95% CI) ^a

1

1.24 (0.92–1.66)

1.36 (1.02–1.82)

1.17 (0.87–1.57)

1.55 (1.17–2.05)

  Multivariate-adjusted HR (95% CI) ^b

1

1.23 (0.21–1.65)

1.32 (0.99–1.77)

1.11 (0.82–1.50)

1.41 (1.05–1.89)

   < 60 years

  HR (95% CI) ^b

1

1.05 (0.71–1.54)

1.11 (0.76–1.62)

1.07 (0.73–1.57)

1.38 (0.95–2.00)

   > 60 years

  HR (95% CI) ^b

1

1.45 (0.91–2.32)

1.58 (1.00–2.50)

1.08 (0.66–1.76)

1.25 (0.77–2.05)

   < 30

  HR (95% CI) ^b

1

1.26 (0.90–1.77)

1.31 (0.94–1.83)

1.17 (0.83–1.42)

1.42 (1.02–1.99)

   > 30

  HR (95% CI) ^b

1

1.07 (0.58–1.99)

1.35 (0.74–2.46)

0.81 (0.40–1.63)

1.15 (0.59–2.23)

  No. of deaths

220

228

199

  Age-adjusted HR (95% CI) ^a

0.68 (0.53–0.89)

0.96 (0.77–1.21)

0.83 (0.65–1.05)

  Multivariate-adjusted HR (95% CI) ^b

0.88 (0.75–1.03)

0.89 (0.76–1.04)

0.84 (0.71–0.99)

   < 60 years

  HR (95% CI) ^b

0.78 (0.62–0.97)

0.99 (0.80–1.21)

0.80 (0.64–1.01)

   > 60 years

  HR (95% CI) ^b

1.01 (0.80–1.28)

0.81 (0.63–1.04)

0.94 (0.74–1.21)

   < 30

  HR (95% CI) ^b

0.84 (0.71–1.00)

0.87 (0.73–1.04)

0.84 (0.69–1.01)

   > 30

  HR (95% CI) ^b

1.04 (0.70–1.53)

0.97 (0.66–1.42)

0.75 (0.51–1.12)

  No. of deaths

143

117

105

  Age-adjusted HR (95% CI) ^a

0.89 (0.76–1.04)

0.89 (0.76–1.05)

0.79 (0.67–0.93)

  Multivariate-adjusted HR (95% CI) ^b

1.05 (0.86–1.29)

0.84 (0.67–1.04)

0.85 (0.67–1.07)

   < 60 years

  HR (95% CI) ^b

0.91 (0.68–1.21)

0.82 (0.60–1.10)

0.84 (0.61–1.16)

   > 60 years

  HR (95% CI) ^b

1.20 (0.90–1.60)

0.90 (0.65–1.23)

0.88 (0.63–1.23)

   < 30

  HR (95% CI) ^b

1.04 (0.83–1.29)

0.79 (0.62–1.01)

0.85 (0.66–1.09)

   > 30

  HR (95% CI) ^b

1.08 (0.62–1.87)

1.09 (0.64–1.85)

0.73 (0.41–1.29)

  No. of deaths

77

111

94

  Age-adjusted HR (95% CI) ^a

1.05 (0.86–1.29)

0.84 (0.67–1.04)

0.76 (0.61–0.95)

  Multivariate-adjusted HR (95% CI) ^b

0.67 (0.52–0.87)

0.96 (0.76–1.20)

0.83 (0.65–1.07)

   < 60 years

  HR (95% CI) ^b

0.63 (0.45–0.89)

1.18 (0.89–1.56)

0.77 (0.55–1.08)

   > 60 years

  HR (95% CI) ^b

0.75 (0.50–1.12)

0.68 (0.45–1.03)

1.03 (0.71–1.49)

<30

HR (95% CI) ^b

0.60 (0.44–0.81)

0.98 (0.76–1.26)

0.83 (0.63–1.09)

>30

HR (95% CI) ^b

1.01 (0.59–1.73)

0.85 (0.49–1.48)

0.80 (0.46–1.38)