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Table 3 Change on metabolic parameters and macronutrients consumption in the diet

From: Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial

 Wk0Wk10pa
Insulin, AUC
 48 mg sucralose9262 ± 422511,398 ± 66410.02
 96 mg sucralose6962 ± 48998394 ± 55670.12
 Control9054 ± 55719397 ± 51260.65
 pb0.1350.125 
Glucose, AUC
 48 mg sucralose18,267 ± 285819,408 ± 29040.05
 96 mg sucralose18,019 ± 470518,380 ± 36770.66
 Control17,820 ± 287217,870 ± 35570.91
 pb0.8830.195 
Matsuda
 48 mg sucralose6.04 ± 3.194.86 ± 2.130.01
 96 mg sucralose7.93 ± 4.637.09 ± 4.720.30
 Control6.8 ± 3.356.14 ± 3.410.09
 pb0.140.05 
Max [Glu]
 48 mg sucralose133.06 ± 20.79141.17 ± 18.590.09
 96 mg sucralose133.45 ± 29.72137.61 ± 25.330.46
 Control131.94 ± 21.19135.12 ± 23.530.41
 pb0.960.56 
Max [Ins]
 48 mg sucralose106.10 ± 58130.9 ± 60.510.01
 96 mg sucralose85.42 ± 42.6790.42 ± 50.410.48
 Control100 ± 56.07108.94 ± 62.150.34
 pb0.290.02 
Time to max [Glu]
 48 mg sucralose34 ± 18.4540.5 ± 23.350.11
 96 mg sucralose36.77 ± 20.0634.84 ± 19.510.58
 Control36.18 ± 9.8536.18 ± 20.271.00
 pb0.780.55 
Time to Max [Ins]
 48 mg sucralose40.5 ± 14.8238.5 ± 20.350.58
 96 mg sucralose40.65 ± 17.445.48 ± 17.530.23
 Control45 ± 19.1948.09 ± 23.870.50
 pb0.490.17 
BMI, kg/m2
 48 mg sucralose24.2 ± 2.924.2 ± 3.10.47
 96 mg sucralose23.7 ± 3.323.6 ± 3.20.56
 Control24.2 ± 3.824.1 ± 3.90.32
 pb0.840.76 
Carbohydrates, g/d
 48 mg sucralose227.9 ± 59.3252.9 ± 86.70.18
 96 mg sucralose264.7 ± 133.9286.5 ± 132.70.42
 Control289.4 ± 118.4250.7 ± 123.50.12
 pb0.080.42 
Lipids, g/d
 48 mg sucralose67.6 ± 43.481.6 ± 40.40.10
 96 mg sucralose69.2 ± 43.474.2 ± 40.90.63
 Control71.6 ± 59.962.1 ± 26.60.29
 pb0.950.11 
Proteins, g/d
 48 mg sucralose94.4 ± 60.697.47 ± 44.40.86
 96 mg sucralose100.8 ± 44.494.9 ± 82.90.32
 Control103.9 ± 74.884.7 ± 32.90.09
 pb0.8240.427 
Energy, Kcal/d
 48 mg sucralose1935.9 ± 681.82170.7 ± 732.30.10
 96 mg sucralose2133.1 ± 965.82235.7 ± 917.50.65
 Control22 64.8 ± 1247.21941.6 ± 710.70.09
 pb0.420.30 
HbA1c
 48 mg sucralose5.23 ± 0.215.26 ± 0.260.51
 96 mg sucralose5.15 ± 0.35.25 ± 0.260.03
 Control5.22 ± 0.235.24 ± 0.240.55
 pb0.380.94 
  1. AUC area under the curve, BMI body mass index, Hb1Ac hemoglobin glycated, HOMA homeostatic model assessment, Wk0 week 0, Wk10 week 10, 48 mg (n = 30); 96 mg (n = 31); Control (n = 34). Media ± standard deviation
  2. a Two-tailed paired-t tests; b Differences between groups, One-Way ANOVA