Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial

Bueno-Hernández, Nallely; Esquivel-Velázquez, Marcela; Alcántara-Suárez, Raúl; Gómez-Arauz, Angélica Y.; Espinosa-Flores, Aranza J.; de León-Barrera, Karen L.; Mendoza-Martínez, Viridiana M.; Sánchez Medina, Gabriela A.; León-Hernández, Mireya; Ruiz-Barranco, Alejandra; Escobedo, Galileo; Meléndez, Guillermo

doi:10.1186/s12937-020-00549-5

Table 3 Change on metabolic parameters and macronutrients consumption in the diet

From: Chronic sucralose consumption induces elevation of serum insulin in young healthy adults: a randomized, double blind, controlled trial

	Wk0	Wk10	p^a
Insulin, AUC
48 mg sucralose	9262 ± 4225	11,398 ± 6641	0.02
96 mg sucralose	6962 ± 4899	8394 ± 5567	0.12
Control	9054 ± 5571	9397 ± 5126	0.65
p^b	0.135	0.125
Glucose, AUC
48 mg sucralose	18,267 ± 2858	19,408 ± 2904	0.05
96 mg sucralose	18,019 ± 4705	18,380 ± 3677	0.66
Control	17,820 ± 2872	17,870 ± 3557	0.91
p^b	0.883	0.195
Matsuda
48 mg sucralose	6.04 ± 3.19	4.86 ± 2.13	0.01
96 mg sucralose	7.93 ± 4.63	7.09 ± 4.72	0.30
Control	6.8 ± 3.35	6.14 ± 3.41	0.09
p^b	0.14	0.05
Max [Glu]
48 mg sucralose	133.06 ± 20.79	141.17 ± 18.59	0.09
96 mg sucralose	133.45 ± 29.72	137.61 ± 25.33	0.46
Control	131.94 ± 21.19	135.12 ± 23.53	0.41
p^b	0.96	0.56
Max [Ins]
48 mg sucralose	106.10 ± 58	130.9 ± 60.51	0.01
96 mg sucralose	85.42 ± 42.67	90.42 ± 50.41	0.48
Control	100 ± 56.07	108.94 ± 62.15	0.34
p^b	0.29	0.02
Time to max [Glu]
48 mg sucralose	34 ± 18.45	40.5 ± 23.35	0.11
96 mg sucralose	36.77 ± 20.06	34.84 ± 19.51	0.58
Control	36.18 ± 9.85	36.18 ± 20.27	1.00
p^b	0.78	0.55
Time to Max [Ins]
48 mg sucralose	40.5 ± 14.82	38.5 ± 20.35	0.58
96 mg sucralose	40.65 ± 17.4	45.48 ± 17.53	0.23
Control	45 ± 19.19	48.09 ± 23.87	0.50
p^b	0.49	0.17
BMI, kg/m²
48 mg sucralose	24.2 ± 2.9	24.2 ± 3.1	0.47
96 mg sucralose	23.7 ± 3.3	23.6 ± 3.2	0.56
Control	24.2 ± 3.8	24.1 ± 3.9	0.32
p^b	0.84	0.76
Carbohydrates, g/d
48 mg sucralose	227.9 ± 59.3	252.9 ± 86.7	0.18
96 mg sucralose	264.7 ± 133.9	286.5 ± 132.7	0.42
Control	289.4 ± 118.4	250.7 ± 123.5	0.12
p^b	0.08	0.42
Lipids, g/d
48 mg sucralose	67.6 ± 43.4	81.6 ± 40.4	0.10
96 mg sucralose	69.2 ± 43.4	74.2 ± 40.9	0.63
Control	71.6 ± 59.9	62.1 ± 26.6	0.29
p^b	0.95	0.11
Proteins, g/d
48 mg sucralose	94.4 ± 60.6	97.47 ± 44.4	0.86
96 mg sucralose	100.8 ± 44.4	94.9 ± 82.9	0.32
Control	103.9 ± 74.8	84.7 ± 32.9	0.09
p^b	0.824	0.427
Energy, Kcal/d
48 mg sucralose	1935.9 ± 681.8	2170.7 ± 732.3	0.10
96 mg sucralose	2133.1 ± 965.8	2235.7 ± 917.5	0.65
Control	22 64.8 ± 1247.2	1941.6 ± 710.7	0.09
p^b	0.42	0.30
HbA1c
48 mg sucralose	5.23 ± 0.21	5.26 ± 0.26	0.51
96 mg sucralose	5.15 ± 0.3	5.25 ± 0.26	0.03
Control	5.22 ± 0.23	5.24 ± 0.24	0.55
p^b	0.38	0.94

AUC area under the curve, BMI body mass index, Hb1Ac hemoglobin glycated, HOMA homeostatic model assessment, Wk0 week 0, Wk10 week 10, 48 mg (n = 30); 96 mg (n = 31); Control (n = 34). Media ± standard deviation
^a Two-tailed paired-t tests; ^b Differences between groups, One-Way ANOVA

Back to article page

ISSN: 1475-2891

Contact us

General enquiries: journalsubmissions@springernature.com

Nutrition Journal

Contact us