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Table 2 Characteristics of included studies in the systematic-review1

From: Effects of resistant starch interventions on circulating inflammatory biomarkers: a systematic review and meta-analysis of randomized controlled trials

First Author, Year (Ref)

Study design

Country

Age range

Gender

Participants (Intervention/control)

Intervention Type

Duration/week

Intervention Dose

Notes about subjects

Study quality

outcome

Aliasgharzadeh et al. [26]

RCT-parallel

Iran

30–65

F

30/25

resistant dextrin/maltodextrin

8

10

type 2 diabetes

G

IL-6, TNF-a, CRP

Peterson et al. [17]

RCT-parallel

United States

35–75

M/F

29/30

HAM-RS2/Amylopectin

12

45

prediabetes

F

TNF-a

Alfa et al. [27]

RCT-parallel

Canada

30–50

M/F

21/21

MSprebiotic/amioca

12

30

Healthy subjects

G

TNF-a, CRP

Karimi et al. [20]

RCT-parallel

Iran

30–65

F

28/28

Hi-maize 260/ maltodextrin

8

10

type 2 diabetes

G

CRP

Tayebi Khosroshahiet al [18].

RCT-parallel

Iran

≥18

M/F

23/21

HAM-RS2/waxy starch

8

20 g/d during first 4wk and 25 g/d during second 4 wk

patients on maintenance hemodialysis

G

CRP

IL-6, TNF-a

Meng et al. [28]

parallel, open-label trial

China

18–80

M/F

34/36

high-RS,low-protein flour

12

17

Patients With Early Type 2 Diabetic Nephropathy

P

Laffin et al. [29]

RCT-parallel

Iran

 

M/F

9/11

HAM-RS2/regular wheat flour

8

20 g/d during first 4wk and 25 g/d during second 4 wk

end-stage renal disease patients

G

IL-6, TNF-a

Esgalhado et al. [30]

Pilot RCT-parallel

Brazil

≥18

M/F

15/26

Hi-maize 260/manioc flour

4

16

hemodialysis patients

G

IL-6, CRP

Pourghassem Gargari et al. [31]

RCT-parallel

Iran

30–65

F

28/32

Hi-maize 260/maltodextrin

8

10

type 2 diabetes

G

IL-6, TNF-a, CRP

Lambert-Porcheron et al. [32]

randomized cross-over

France

20–65

M/F

20/20

high slowly digestible starch/low slowly digestible starch

6

10

healthy overweight subjects with metabolic risk

P

TNF-a, CRP

Schioldan et al. [33]

cross-over

Denmark

39–75

M/F

19/19

67 g dietary fiber(16 g arabinoxylan+ 21 g RS)/ 18 g dietary fiber (4 g arabinoxylan+ 3 g RS)

10

21

Metabolic syndrome

P

IL-6

Gholizadeh Shamasbi et al. [34]

RCT-parallel

Iran

18–45

F

31/31

resistant dextrin/ maltodextrin

12

20

polycystic ovarian syndrome

G

IL-6

Penn-Marshall et al. [35]

cross-over

USA

Mean: 36.6 ± 1.55

M/F

15/15

Hi-maize 260/no RS

8

12

Subjects at risk for type 2 DM.

P

CRP

  1. CRP C - reactive protein, IL-6 interleukin 6, G good quality, F fair quality, P poor quality, RS resistant starch