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Table 2 Post-transplant outcome relative to nutritional support

From: Enteral nutrition protects children undergoing allogeneic hematopoietic stem cell transplantation from blood stream infections

 

EN group (n = 14)

PN group (n = 28)

p

Engrafment:

 Neutrophil, days, mean

17.31

16.86

0.78

 PLT > 20*109, days, mean

35.67

23.14

0.04

 PLT > 50*109, days, mean

36.40

30,89

0.45

 Duration of G-CSF, days, mean

11.62

10.46

0.51

Oral mucositis:

 Grade 3–4, n, (%)

5 (35.7)

3 (10.7)

0.10

 Duration, days, mean

13.46

13.54

0.98

aGvHD:

 Grade I-IV, n, (%)

6 (42.9)

13 (46.4)

1.00

 Grade III-IV, n, (%)

1 (16.7)

5 (38.46)

0.52

 Gut aGvHD, n, (%)

4 (28.6)

8 (28.6)

1.00

 Gut aGvHD +++/++++, n, (%)

0 (0)

5 (17.9)

0.08

 Steroid Resistant Gut aGvHD, n, (%)

0 (0)

6 (21.4)

0.06

Infections:

 BSI, n, (%)

2 (14.3)

15 (53.6)

0.02

 Duration of fever in the first 30 days post HSCT, days, mean

8.00

11.21

0.07

 Length of Antibiotic therapy in the first 30 days post HSCT, days, mean

18.54

19.38

0.65

VOD, n, (%)

2 (14.3)

5 (17.9)

1.00

Length of hospital stay, days, mean

71.8

60.1

0.28

Transfer to ICU, n, (%)

2 (14.3)

3 (10.7)

1.00

Nutritional Support:

 Length of nutritional support, days, mean

20.71

30.71

0.09

 Start of oral realimentation, days, mean

20.85

26.96

0.08

Nutritional Parameters

 Lowest weight, Kg, mean

29.78

36.63

0.31

 Maximum weight loss %, mean

11.5

9.9

0.44

 Weight loss > 10%, n, (%)

7 (50)

9 (32.2)

0.30

Metabolic Parameters:

 Albumin transfusions, U, mean

6,31

13.79

0.14

 Hypophosphatemia, n, (%)

8 (57,1)

21 (75)

0.10

 γGT and/or direct bilirubin elevation, n, (%)

11 (78,6)

24 (85.7)

0.26

  1. Abbreviations: EN= Enteral Nutrition, PN= Parenteral Nutrition, PLT= Platelets, G-CSF= Granulocyte-Colony Stimulating Factor, aGvHD= Acute Graft versus Host Disease, BSI= Blood Stream Infections, HSCT= Hematopoietic Stem Cell Transplantation, VOD= Veno Occlusive Disease, ICU= Intensive Care Unit, γGT= Gamma.glutamyltransferase
  2. Statistical analysis used to calculate the P value: qualitative variables were compared using Fisher’s exact test, while means were compared with t-test corrected in case of unequal variances. p < 0.05 were considered statistically significant and underlined in the table