Effects of cinnamon supplementation on expression of systemic inflammation factors, NF-kB and Sirtuin-1 (SIRT1) in type 2 diabetes: a randomized, double blind, and controlled clinical trial

Table 3 The comparison of clinical variables in two groups before and after the intervention

Variables	Cinnamon Group, n = 20	Placebo Group, n = 19	P^**
Before Treatment
hs-CRP (ng/ml)	4392.80 ± 3969.60	6209.52 ± 4217.05	0.06
TNF-α (pg/ml)	28.72 ± 35.52	17.12 ± 9.02	0.21
IL-6 (pg/ml)	6.08 ± 2.40	6.33 ± 2.66	0.76
NF-kB (ng/ml)	6.02 ± 15.74	1.96 ± 2.73	0.34
SIRT1 (ng/ml)	5.54 ± 6.96	3.34 ± 0.29	0.13
After Treatment
hs-CRP (ng/ml)	3139.45 ± 2732.06	4155.42 ± 3422.95	0.29
Differences	- 1253.35 ± 2992.23	- 2054.10 ± 3228.78	0.21
P^*	0.22	0.008
TNF-α (pg/ml)	28.88 ± 26.97	17.60 ± 8.56	0.27
Differences	- 1.84 ± 12.20	0.47 ± 8.60	0.81
P^*	0.90	0.84
IL-6 (pg/ml)	5.68 ± 1.33	6.09 ± 1.98	0.52
Differences	−0.40 ± 2.23	- 0.23 ± 2.82	0.84
P^*	0.60	0.85
NF-kB (ng/ml)	3.48 ± 6.45	0.85 ± 0.58	0.02
Differences	- 2.53 ± 10.80	- 1.11 ± 2.49	0.26
P^*	0.69	0.055
SIRT1 (ng/ml)	6.16 ± 12.13	3.62 ± 1.26	0.51
Differences	0.62 ± 5.82	0.28 ± 1.27	0.23
P^*	0.39	0.38

Data are presented as mean ± standard deviation (SD) for continuous variables. * P was applied for the comparisons among groups, with the use of Student’s t-test for continuous variables, Mann–Whitney test for variables with non-normal distribution. ** P was used for the comparisons between groups, with use of paired t-test for continuous variables, Wilcoxon test for variables with non-normal distribution. Difference is significant at P < 0.050. Abbreviations: hs-CRP high-sensitive C-Reactive Protein, TNF-α Tumor Necrosis Factor-alpha, IL-6 Interleukine-6, NF-kB Nuclear factor-Kappa B, SIRT1 Sirtuin-1

ISSN: 1475-2891