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Table 4 Risk for breast cancer according to quartiles of the low-carbohydrate-diet score with stratification by menopausal status

From: Adherence to the low carbohydrate diet and the risk of breast Cancer in Iran

 OR (95% CI)PTrenda
Quartile 1Quartile 2Quartile 3Quartile 4
Total
 No.of cases/controls (412/456)130/13287/110127/14068/74 
 Crude10.80 (0.55–1.16)0.92 (0.65–1.29)0.93 (0.62–1.40)0.81
 Model 110.82 (0.57–1.21)0.95 (0.67–1.35)0.93 (0.61–1.41)0.89
 Model 210.79 (0.53–1.20)1.05 (0.73–1.53)0.97 (0.62–1.51)0.79
 Model 310.80 (0.53–1.22)1.14 (0.76–1.71)0.99 (0.62–1.58)0.46
Model 410.84 (0.55–1.29)1.22 (0.81–1.84)1.00 (0.63–1.60)0.37
Premenopause
 No.of cases/controls (267/300)90/8158/7676/9943/44 
 Crude10.68 (0.43–1.08)0.69 (0.45–1.05)0.87 (0.52–1.47)0.28
 Model 110.70 (0.44–1.11)0.70 (0.45–1.07)0.88 (0.52–1.49)0.31
 Model 210.64 (0.39–1.06)0.77 (0.48–1.21)0.91 (0.52–1.59)0.55
 Model 310.68 (0.40–1.14)0.82 (0.50–1.36)0.92 (0.51–1.66)0.75
 Model 410.72 (0.42–1.22)0.89 (0.53–1.47)0.93 (0.51–1.69)0.88
Postmenopause
 No.of cases/controls (145/147)40/4929/3351/3825/27 
 Crude11.07 (0.56–2.06)1.64 (0.91–2.97)1.13 (0.57–2.25)0.23
 Model 111.13 (0.58–2.18)1.78 (0.97–3.23)1.13 (0.57–2.27)0.18
 Model 211.09 (0.52–2.31)1.94 (1.00–3.76)1.32 (0.61–2.84)0.11
 Model 311.18 (0.53–2.61)2.50 (1.18–5.32)1.46 (0.65–3.27)0.06
 Model 411.20 (0.54–2.66)2.64 (1.23–5.67)1.46 (0.65–3.28)0.05
  1. aTrend based on median values of each quartile
  2. Model 1: Adjusted for age
  3. Model 2: further adjusted for physical activity, family history of breast cancer, menopausal hormone use, education, parity, oral contraceptive use, cigar smoking, alcohol consumption, fertility treatment, marital status
  4. Model 3: further adjusted for vitamin E, iron, vitamin B6, folic acid, vitamin A
  5. Model 4: additional adjusted for BMI