Table 3 Causal odds ratios from MR analysis for the associations of 25(OH)D with metabolic syndrome components (dichotomous variables) and metabolic syndrome
|  | ORXY [per 10 nmol/L increase in 25(OH)D] | GRScombined | GRSsynthesis | GRSmetabolism | |||
|---|---|---|---|---|---|---|---|
ORZY [per 1 unit increase in GRScombined] | ORIV [per 10 nmol/L increase in 25(OH)D] | ORZY [per 1 unit increase in GRSsynthesis] | ORIV [per 10 nmol/L increase in 25(OH)D] | ORZY [per 1 unit increase in GRSmetabolism] | ORIV [per 10 nmol/L increase in 25(OH)D] | ||
Central obesity | 1.023 (0.987, 1.061) | 1.014 (0.982, 1.047) | 0.867 (0.629, 1.195) | 1.008 (0.964, 1.055) | 0.909 (0.532, 1.556) | 1.024 (0.975, 1.075) | 0.834 (0.574, 1.210) |
Raised fasting plasma glucose | 1.016 (0.981, 1.052) | 1.027 (0.994, 1.060) | 0.767 (0.555, 1.061) | 1.047 (1.001, 1.095) | 0.578 (0.321, 0.980) | 0.997 (0.951, 1.046) | 1.034 (0.717, 1.461) |
Raised triglyceride | 0.833 (0.803, 0.864) | 0.966 (0.965, 1.027) | 1.042 (0.757, 1.435) | 0.988 (0.945, 1.033) | 1.154 (0.674, 1.976) | 1.008 (0.961, 1.057) | 0.941 (0.658, 1.344) |
Reduced high-density lipoprotein | 1.006 (0.969, 1.044) | 0.991 (0.959, 1.024) | 1.096 (0.780, 1.540) | 0.983 (0.939, 1.030) | 1.224 (0.697, 2.149) | 1.003 (0.955, 1.053) | 0.978 (0.674, 1.416) |
Raised blood pressure | 1.043 (1.004, 1.084) | 0.978 (0.946, 1.011) | 1.251 (0.889, 1.761) | 0.978 (0.933, 1.025) | 1.300 (0.739, 2.286) | 0.975 (0.928, 1.025) | 1.209 (0.832, 1.754) |
Metabolic syndrome | 0.921 (0.888, 0.954) | 0.977 (0.966, 1.030) | 1.031 (0.749, 1.420) | 0.994 (0.950, 1.041) | 1.074 (0.628, 1.837) | 1.002 (0.955, 1.052) | 0.985 (0.680, 1.428) |