Table 2 Causal coefficients from MR analysis for the associations of 25(OH)D with metabolic syndrome components (continuous variables)
|  | βXY [per 10 nmol/L increase in 25(OH)D] | GRScombined | GRSsynthesis | GRSmetabolism | |||
|---|---|---|---|---|---|---|---|
βZY [per 1 unit increase in GRScombined] | βIV [per 10 nmol/L increase in 25(OH)D] | βZY [per 1 unit increase in GRSsynthesis] | βIV [per 10 nmol/L increase in 25(OH)D] | βZY [per 1 unit increase in GRSmetabolism] | βIV [per 10 nmol/L increase in 25(OH)D] | ||
Waist circumference | 0.128 (−0.005, 0.262) | −0.038 (−0.155, 0.080) | 0.388 (− 0.814,1.590) | − 0.061 (− 0.227, 0.104) | 0.726 (−1.245, 2.697) | − 0.004 (− 0.180, 0.172) | 0.030 (−1.306, 1.366) |
Fasting plasma glucose | − 0.012 (− 0.034, 0.011) | 0.017 (− 0.002, 0.037) | −0.174 (− 0.376, 0.029) | 0.027 (− 0.001, 0.055) | −0.321 (− 0.660, 0.018) | 0.004 (− 0.026, 0.034) | −0.030 (− 0.253, 0.193) |
ln(triglycerides) | − 0.059 (− 0.067, − 0.051) | 0.002 (− 0.004, 0.009) | −0.020 (− 0.080, 0.040) | 0.002 (− 0.007, 0.012) | −0.024 (− 0.141, 0.093) | 0.003 (− 0.007, 0.013) | −0.023 (− 0.097, 0.051) |
High-density lipoprotein | − 0.003 (− 0.008, 0.001) | 0.001 (− 0.003, 0.005) | −0.010 (− 0.050, 0.030) | 0.001 (− 0.005, 0.007) | −0.012 (− 0.082, 0.058) | 0.001 (− 0.005, 0.007) | −0.008 (− 0.053, 0.037) |
Systolic blood pressure | 0.468 (0.168, 0.768) | 0.018 (−0.246, 0.283) | − 0.184 (−2.884, 2.516) | 0.064 (− 0.309, 0.437) | −0.762 (−5.200, 3.676) | −0.054 (− 0.451, 0.344) | 0.409 (− 2.606, 3.424) |
Diastolic blood pressure | 0.287 (0.092, 0.481) | − 0.006 (− 0.177, 0.166) | 0.061 (− 1.679, 1.801) | −0.014 (− 0.256, 0.228) | 0.167 (− 2.703, 3.037) | 0.007 (− 0.251, 0.264) | −0.053 (− 1.998, 1.892) |