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Table 1 Characteristics of study participants according to the weighted vitamin D genetic risk score (GRScombined) stratified by gender (n = 10655)

From: Association of 25-hydroxyvitamin D with cardiometabolic risk factors and metabolic syndrome: a mendelian randomization study

Characteristic GRScombined P for trend
Quartile 1 Quartile 2 Quartile 3 Quartile 4
Men
 GRScombined ≤2.480 2.481–3.520 3.521–4.640 ≥4.641  
 N 1072 1066 995 952  
 Age, yr 55.5 (13.2) 55.5 (13.2) 55.7 (13.1) 55.8 (13.0) 0.547
 25(OH)D, mmol/L 45.3 (14.1) 44.0 (13.3) 42.7 (13.6) 41.5 (12.7) < 0.001
 Fasting plasma glucose, mmol/L 5.67 (1.43) 5.72 (1.54) 5.76 (1.63) 5.87 (1.81) 0.005
 Body mass index, kg/m2 25.0 (3.4) 24.9 (3.4) 25.0 (3.6) 25.0 (3.5) 0.719
 Waist circumference, cm 85.1 (9.9) 85.2 (9.2) 85.1 (9.5) 85.3 (9.5) 0.714
 Triglycerides, mmol/L 1.85 (1.93) 1.85 (1.95) 1.91 (1.93) 1.91 (1.60) 0.345
 High-density lipoprotein, mmol/L 1.32 (0.32) 1.33 (0.32) 1.33 (0.33) 1.31 (0.31) 0.566
 Systolic blood pressure, mmHg 135 (21) 134 (20) 135 (21) 134 (21) 0.731
 Diastolic blood pressure, mmHg 82 (13) 82 (13) 82 (13) 82 (13) 0.224
 Current smoker, % 44.1 44.7 45.2 46.9 0.712
 Central obesity, % 31.8 32.6 32.1 33.2 0.579
 Raised fasting plasma glucose, % 36.6 38.1 39.8 42.0 0.006
 Raised triglycerides, % 42.1 44.4 43.9 42.9 0.796
 Reduced high-density lipoprotein, % 25.3 26.0 26.3 28.4 0.105
 Raised blood pressure, % 67.8 68.9 68.6 65.7 0.286
 Metabolic syndrome, % 21.9 25.0 24.4 23.7 0.416
 Rural/urban residence, % 49.3/50.7 49.2/50.8 49.7/50.3 48.9/51.1 0.936
 Low/high econmic status, % 33.9/66.1 34.2/65.8 35.7/64.3 36.7/63.3 0.129
Women
 GRScombined ≤2.440 2.441–3.480 3.481–4.640 ≥4.641  
 N 1601 1189 1493 1418  
 Age, yr 54.0 (12.8) 54.4 (12.9) 54.5 (12.8) 54.7 (12.3) 0.120
 Premenopausal women, % 47.7 47.4 46.1 45.3 0.161
 25(OH)D, mmol/L 40.3 (12.5) 38.5 (11.9) 38.7 (12.1) 37.4 (11.2) < 0.001
 Fasting plasma glucose, mmol/L 5.58 (1.43) 5.62 (1.43) 5.61 (1.46) 5.57 (1.32) 0.868
 Body mass index, kg/m2 24.3 (3.6) 24.5 (3.5) 24.4 (3.7) 24.4 (3.7) 0.668
 Waist circumference, cm 78.3 (9.8) 78.9 (9.8) 78.6 (10.1) 78.5 (9.6) 0.592
 Triglycerides, mmol/L 1.52 (1.05) 1.59 (1.18) 1.48 (1.06) 1.55 (1.07) 0.985
 High-density lipoprotein, mmol/L 1.44 (0.31) 1.45 (0.31) 1.47 (0.32) 1.45 (0.32) 0.238
 Systolic blood pressure, mmHg 131 (22) 132 (21) 131 (22) 132 (22) 0.258
 Diastolic blood pressure, mmHg 77 (13) 78 (13) 78 (13) 78 (13) 0.424
 Current smoker, % 1.9 2.0 2.5 2.0 0.487
 Central obesity, % 43.8 46.5 45.2 47.0 0.150
 Raised fasting plasma glucose, % 33.4 35.4 33.8 34.1 0.892
 Raised triglycerides, % 36.1 36.3 31.3 35.7 0.244
 Reduced high-density lipoprotein, % 39.8 38.0 34.6 38.1 0.110
 Raised blood pressure, % 56.6 58.9 56.0 57.7 0.905
 Metabolic syndrome, % 30.0 32.4 29.8 31.2 0.809
 Rural/urban residence, % 44.9/55.1 45.8/54.2 47.2/52.8 46.9/53.1 0.193
 Low/high econmic status, % 32.5/67.5 31.7/68.3 32.4/67.6 32.5/67.5 0.910
  1. The data are summarized as the mean (SD) for continuous variables or as a numerical proportion for categorical variables. P for trend was calculated by ANOVA and chi-square tests. 25(OH)D, 25-hydroxyvitamin D; GRS, genetic risk score