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Table 3 Subgroup and sensitivity analysis- vitamin D and atrial fibrillation incident, per 10 ng/ml increase

From: The relationship between vitamin D and risk of atrial fibrillation: a dose-response analysis of observational studies

ItemsNumber of studiesRR (95%CI)PP* h (%)P#
Result of primary analysis100.88 (0.78–0.98)0.0385
Mean age< 65 years30.87 (0.72–1.06)0.17830.15
> 65 years70.68 (0.52–0.89)0.00595
Study designCase-control40.13 (0.04–0.44)< 0.001740.001
Cohort60.96 (0.93–0.99)0.0070
Sample size< 200050.21 (0.06–0.69)< 0.001960.01
≥200050.95 (0.92–0.99)0.0050
Case< 20040.21 (0.06–0.69)0.007740.001
≥20060.97 (0.96–0.98)0.0010
RegionEuropean10.96 (0.91–1.01)0.140.006
America50.96 (0.92–0.99)0.020
Asia40.13 (0.04–0.44)0.00174
Study quality< 620.49 (0.12–2.06)0.33920.32
≥680.74 (0.61–0.91)0.00494
Repeated with fixed model 100.97 (0.96–0.98)< 0.00193
Exclusion of subjects     
 Case-control omitted60.96 (0.93–0.99)0.0070
 Low quality excluded80.74 (0.61–0.91)0.00494
 Not adjusted age excluded90.75 (0.64–0.88)< 0.00194
 Not adjusted BMI excluded80.77 (0.66–0.89)< 0.00194
 Not adjusted sex excluded90.75 (0.64–0.88)< 0.00194
 Not adjusted BMI excluded60.74 (0.60–0.92)880.006
  1. *P value of heterogeneity. #P for subgroup of subgroup. BMI body mass index; RR Ratio risk, CI confidence intervals